KIDINS220 and NGFR

Number of citations of the paper that reports this interaction (PMID 11150334)
29

Data Source:
HPRD (in vivo, two hybrid)

		KIDINS220	NGFR
Gene Name		kinase D-interacting substrate, 220kDa	nerve growth factor receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Late Endosome Cytosol Membrane Integral Component Of Membrane Protein Complex	Extracellular Region Nucleoplasm Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Neuronal Postsynaptic Density
	Molecular Function	PDZ Domain Binding	Signal Transducer Activity Receptor Activity Transmembrane Signaling Receptor Activity Death Receptor Activity Protein Binding Rab GTPase Binding Ubiquitin Protein Ligase Binding Nerve Growth Factor Binding
	Biological Process	Activation Of MAPKK Activity In Utero Embryonic Development Positive Regulation Of Neuron Projection Development Cytoplasmic Transport Nerve Growth Factor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Dendrite Morphogenesis Cellular Response To Nerve Growth Factor Stimulus	Intracellular Protein Transport Axon Guidance Central Nervous System Development Detection Of Temperature Stimulus Nerve Development Hair Follicle Morphogenesis Membrane Protein Intracellular Domain Proteolysis Circadian Regulation Of Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Regulation Of Hair Follicle Development Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Glucose Import In Response To Insulin Stimulus
Pathways		ARMS-mediated activation Signalling to ERKs Signalling by NGF Prolonged ERK activation events NGF signalling via TRKA from the plasma membrane	Regulated proteolysis of p75NTR Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes p75NTR regulates axonogenesis p75NTR negatively regulates cell cycle via SC1 Cell death signalling via NRAGE, NRIF and NADE Axonal growth stimulation Ceramide signalling p75 NTR receptor-mediated signalling Axonal growth inhibition (RHOA activation) NRIF signals cell death from the nucleus NRAGE signals death through JNK p75NTR signals via NF-kB NFG and proNGF binds to p75NTR NADE modulates death signalling
Drugs
Diseases
GWAS		Neutrophil count ( 21507922)	Immune reponse to smallpox (secreted IL-2) ( 22610502) Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: CDC73 CRKL MOB4 MYC NGFR NTRK1 NTRK2 NTRK3 PRKD1	45 interactors: ANXA7 BEX1 CAV1 CD80 CDKN1A FSCN1 GRB2 H2AFX IL2 KIDINS220 LINGO1 MAG MAGED1 MAGEH1 MAPK1 MAPK3 NDN NDNL2 NFKBIB NGF NGFRAP1 NTF4 NTRK1 NTRK2 NTRK3 PRKACB PTPN13 RCC1 RIPK2 RPN2 RTN4R SHC1 SMN1 SORT1 STMN2 TK1 TRA2B TRADD TRAF2 TRAF4 TRAF6 TRIM37 TTR UFD1L ZNF274
Entrez ID		57498	4804
HPRD ID		17235	01197
Ensembl ID		ENSG00000134313	ENSG00000064300
Uniprot IDs		Q7Z322 Q9ULH0	P08138
PDB IDs			3EWV
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Neuron Projection Development Cellular Response To Organic Substance Positive Regulation Of Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Neuron Differentiation Regulation Of Cell Proliferation Regulation Of Neuron Projection Development Response To Organic Substance Positive Regulation Of Neurogenesis Regulation Of Cell Differentiation Regulation Of Signal Transduction Circadian Rhythm Negative Regulation Of Cell Death Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Signaling Regulation Of Neuron Differentiation Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Mechanoreceptor Differentiation Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Axonogenesis Regulation Of Neurogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Phosphorylation Rhythmic Process Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Cell Proliferation Regulation Of Fibroblast Proliferation Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Modification Process	Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Catalytic Activity Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development TRIF-dependent Toll-like Receptor Signaling Pathway Response To Stimulus Developmental Process Regulation Of MAP Kinase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Tagcloud ?		acts ankyrin arms cdk cdk4 cdks cyclins ephrin g1 hyperphosphorylation interacting nervous neuroblastoma neurotrophin never organizing platform prb primarily prominent regulate repeat rich scaffold slowdown spanning tightly upregulation	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Difference) ?		acts ankyrin arms cdk cdk4 cdks cyclins ephrin g1 hyperphosphorylation interacting nervous neuroblastoma neurotrophin never organizing platform prb primarily prominent regulate repeat rich scaffold slowdown spanning tightly upregulation	acidophilia astrocyte axotomized chat choline cholinergic cresyl depressed die elicit fate ff fimbria fornix immunoreactive itfs jun jund krox lose medial microglial mystery parvalbumin septal septohippocampal transection transferase violet
Tagcloud (Intersection) ?