RASGRF1 and RHOA

Number of citations of the paper that reports this interaction (PMID 10220378)
15

Data Source:
HPRD (in vivo)

		RASGRF1	RHOA
Gene Name		Ras protein-specific guanine nucleotide-releasing factor 1	ras homolog family member A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Cell Junction Midbody Cleavage Furrow Apical Junction Complex Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	GTPase Activity Protein Binding GTP Binding Myosin Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Long-term Memory Cell Proliferation Neuron Projection Development Positive Regulation Of Ras GTPase Activity Activation Of Rac GTPase Activity Regulation Of Rac Protein Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity	Transforming Growth Factor Beta Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Viral Process Substantia Nigra Development Actin Cytoskeleton Organization Platelet Activation Regulation Of Cell Migration Positive Regulation Of Cytokinesis Regulation Of Osteoblast Proliferation Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Trabecula Morphogenesis Mitotic Spindle Assembly Skeletal Muscle Satellite Cell Migration
Pathways		Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events Ras activation uopn Ca2+ infux through NMDA receptor	Loss of Function of TGFBR2 in Cancer Signaling by GPCR Axon guidance Axonal growth stimulation SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGFBR1 LBD Mutants in Cancer VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Rho GTPase cycle EPHA-mediated growth cone collapse Axonal growth inhibition (RHOA activation) PI3K/AKT activation G beta:gamma signalling through PI3Kgamma EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse TGFBR2 MSI Frameshift Mutants in Cancer Signalling by NGF TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer p75NTR regulates axonogenesis G-protein beta:gamma signalling Loss of Function of SMAD2/3 in Cancer Semaphorin interactions TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer p75 NTR receptor-mediated signalling TGFBR1 KD Mutants in Cancer NGF signalling via TRKA from the plasma membrane Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling GPCR downstream signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Signaling by VEGF Signaling by Rho GTPases GPVI-mediated activation cascade Platelet activation, signaling and aggregation PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer
Drugs			Guanosine-5\'-Diphosphate
Diseases
GWAS		Refractive error ( 23396134 20835236) RR interval (heart rate) ( 20031603)
Protein-Protein Interactions		16 interactors: ADRBK1 CEBPA EHD4 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 TNK2 USP8 YWHAB YWHAE	90 interactors: AKAP13 ARHGAP1 ARHGAP10 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF11 ARHGEF12 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 BCR BIRC2 CAV1 CIT CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DOCK7 DVL2 FAM65B FLNA GMIP GNA12 GNB2L1 HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 MCF2 MCF2L MPRIP NET1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PPP1R12A PRKACA PRKCA PRKCZ RABAC1 RAP1GDS1 RASGRF1 RHPN1 RHPN2 RIPK4 ROCK1 RPN2 RTKN SH3BP1 SMAD2 SMURF1 SMURF2 SPRED2 SRGAP1 TEC TGFBR1 TGM2 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3
Entrez ID		5923	387
HPRD ID		07362	01323
Ensembl ID		ENSG00000058335	ENSG00000067560
Uniprot IDs		A8K270 F8VPA5 J3KQP9 Q13972 Q8IUU5	P61586 Q9BVT0
PDB IDs			1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Locomotion Positive Regulation Of Protein Modification Process Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Response To Organic Substance Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Ras Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Cell Migration Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Cell Motility Signal Transduction Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Mechanoreceptor Differentiation Signaling Regulation Of Cell Death Positive Regulation Of Organelle Organization Cell Communication Protein Autophosphorylation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of Cell Differentiation Activation Of Protein Kinase Activity Defense Response	Positive Regulation Of Rho GTPase Activity Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Rho GTPase Activity Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Signaling Positive Regulation Of Ras GTPase Activity Regulation Of GTPase Activity Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Signal Transduction Signaling Cell Communication Positive Regulation Of Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Rho Protein Signal Transduction Response To Stimulus Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Apoptotic Process Programmed Cell Death Apoptotic Signaling Pathway Cell Death Death Regulation Of Cellular Process Regulation Of Apoptotic Process Ras Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Cell Death Locomotion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Positive Regulation Of Rac GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Chemotaxis Neuron Projection Development
Tagcloud ?		abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns	1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase
Tagcloud (Difference) ?		abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns	1beta a549 acetyltransferase actinomycin bk bronchial c3 cat chloramphenicol constitutively cotransfection eliminated enhancer enhancers exoenzyme hoe immunoreactive kappab microg plasmid q63l reporter secreted stimulate stimulates supernatants t19n transferase
Tagcloud (Intersection) ?