NTF3 and NTRK1

Number of citations of the paper that reports this interaction (PMID 8621424)
8

Data Source:
BioGRID (pull down)

		NTF3	NTRK1
Gene Name		neurotrophin 3	neurotrophic tyrosine kinase, receptor, type 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasmic Membrane-bounded Vesicle	Endosome Early Endosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Neuronal Cell Body Protein Complex Receptor Complex
	Molecular Function	Receptor Binding Neurotrophin P75 Receptor Binding Growth Factor Activity Chemoattractant Activity Nerve Growth Factor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin P75 Receptor Binding Protein Binding ATP Binding Nerve Growth Factor Receptor Activity Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Nerve Growth Factor Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Receptor Internalization Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Neuromuscular Synaptic Transmission Nervous System Development Glial Cell Fate Determination Axon Guidance Brain Development Peripheral Nervous System Development Positive Regulation Of Cell Proliferation Epidermis Development Nerve Development Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Activation Of Ras GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Mechanoreceptor Differentiation Myelination Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Enteric Nervous System Development Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Chemotaxis Induction Of Positive Chemotaxis Smooth Muscle Cell Differentiation Positive Regulation Of Actin Cytoskeleton Reorganization	Activation Of MAPKK Activity Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Aging Learning Or Memory Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Developmental Programmed Cell Death Positive Regulation Of Neuron Projection Development Response To Activity Peptidyl-tyrosine Phosphorylation Olfactory Nerve Development B Cell Differentiation Response To Nutrient Levels Positive Regulation Of Ras GTPase Activity Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Response To Drug Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Ras Protein Signal Transduction Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Sympathetic Nervous System Development Response To Axon Injury Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrostatic Pressure Response To Electrical Stimulus Positive Regulation Of Synaptic Transmission, Glutamatergic Sertoli Cell Development Axonogenesis Involved In Innervation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Nicotine Cellular Response To Nerve Growth Factor Stimulus
Pathways			Retrograde neurotrophin signalling Signalling to ERKs Signalling by NGF Prolonged ERK activation events Activation of TRKA receptors NGF signalling via TRKA from the plasma membrane ARMS-mediated activation TRKA activation by NGF PI3K/AKT activation Signalling to RAS Signalling to STAT3 NGF-independant TRKA activation PLC-gamma1 signalling Signalling to p38 via RIT and RIN Frs2-mediated activation
Drugs			Amitriptyline Imatinib Regorafenib
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BDNF MEOX2 NTRK1 NTRK2 NTRK3	36 interactors: ABL1 ARHGAP32 CAV1 CRK DNAJA3 DYNLL1 FRS2 FRS3 GIPC1 GRB2 IRS1 IRS2 KIDINS220 MAPK3 MATK NEDD4 NEDD4L NGF NGFR NTF3 PIK3R1 PLCG1 PTPN1 PTPN11 RAP1A RASA1 RASGRF1 RUSC1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		4908	4914
HPRD ID		01219	01869
Ensembl ID		ENSG00000185652	ENSG00000198400
Uniprot IDs		P20783	P04629
PDB IDs		1B8K 1BND 1NT3 3BUK	1HE7 1SHC 1WWA 1WWW 2IFG 4AOJ 4F0I 4GT5
Enriched GO Terms of Interacting Partners?		Mechanoreceptor Differentiation Cellular Response To Nerve Growth Factor Stimulus Circadian Rhythm Rhythmic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Projection Development Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Neurogenesis Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Axonogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Phosphorylation Response To Auditory Stimulus Negative Regulation Of Neuron Death Protein Autophosphorylation Response To Mechanical Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Neuron Projection Development Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamate Secretion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Modification Process Learning Or Memory Activation Of Adenylate Cyclase Activity Negative Regulation Of Cell Death Positive Regulation Of Cell Projection Organization Positive Regulation Of Cellular Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Neuron Death Cognition Regulation Of Protein Phosphorylation Regulation Of Synaptic Transmission Epithelium Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Electrical Stimulus Organ Development Positive Regulation Of Protein Metabolic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Kinase Activity Cell Communication Regulation Of Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Cellular Response To Insulin Stimulus Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Catalytic Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Insulin Positive Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Response To Stimulus Response To Peptide Hormone Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Response To Fibroblast Growth Factor Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity
Tagcloud ?		apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Difference) ?		apical debatable expense fate feedback gliogenesis implying layer neocortex neocortical neurogenesis neurotrophin overproduction postmitotic precisely progenitor progenitors repressor rescue sequentially sip1 specification switch switches timing ul vi wherein zeb2	aacr accelerated advancements ago approved developments discov encodes fda fusions harboring next oncd oncogene oncogenic oncology originally precision rationale rearrangements revisit scientific throughput tpm3 transforming trka trkb trkc
Tagcloud (Intersection) ?