NPAS2 and RPL6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NPAS2	RPL6
Gene Name		neuronal PAS domain protein 2	ribosomal protein L6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytosol	Nucleus Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding	DNA Binding RNA Binding Structural Constituent Of Ribosome Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Signal Transduction Central Nervous System Development Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Sleep/wake Cycle Cellular Lipid Metabolic Process Small Molecule Metabolic Process Locomotor Rhythm Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Redox State Negative Regulation Of Cell Death Regulation Of Response To DNA Damage Stimulus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Transcription, DNA-templated Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression	Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Creutzfeldt-Jakob disease (variant) ( 22137330)	Blood pressure ( 21572416) Esophageal cancer ( 21642993)
Protein-Protein Interactions		19 interactors: ARNT2 ARNTL ARNTL2 CREBBP CRX EFS EP300 HESX1 HGS HSP90AA1 KAT2B NCOA3 RARA RASSF7 RHOXF1 RPL6 RXRA TRAF4 ZSCAN1	12 interactors: CSNK2A1 EIF6 FGF2 IL7R IVNS1ABP MAP3K14 ND1 NFKB2 NPAS2 RPL29 SEL1L STAU1
Entrez ID		4862	6128
HPRD ID		09137	04745
Ensembl ID		ENSG00000170485	ENSG00000089009
Uniprot IDs		A2I2P5 F5H027 Q99743	Q02878 Q8TBK5
PDB IDs			3J3B
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression N-terminal Protein Amino Acid Acetylation Rhythmic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signal Transduction Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Signaling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Communication Biosynthetic Process Cellular Nitrogen Compound Metabolic Process N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Histone Acetylation Regulation Of Cellular Process Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Response To Stimulus Intracellular Receptor Signaling Pathway Embryo Development Cellular Response To Heat Intracellular Steroid Hormone Receptor Signaling Pathway	NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Rhythmic Process Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Follicular Dendritic Cell Differentiation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Cell Death
Tagcloud ?		additively bmal1 box circadian clock electrophoretic ems fold heme heterodimer homodimer kd kinetics luciferase maximal metabolite mixture mobility monoxide nad nadph nih3t3 ph rhythms sense sensor shift truncated	60s 80s atpases biogenesis comes ebp2 es39l es7l eukaryote excessively helicases machines mak5 multitude nop1 nop16 nop4 nsa1 nucleolus orchestrate ribosomes rix7 rpf1 rpl14 rpl16 rrnas snornp translate translating
Tagcloud (Difference) ?		additively bmal1 box circadian clock electrophoretic ems fold heme heterodimer homodimer kd kinetics luciferase maximal metabolite mixture mobility monoxide nad nadph nih3t3 ph rhythms sense sensor shift truncated	60s 80s atpases biogenesis comes ebp2 es39l es7l eukaryote excessively helicases machines mak5 multitude nop1 nop16 nop4 nsa1 nucleolus orchestrate ribosomes rix7 rpf1 rpl14 rpl16 rrnas snornp translate translating
Tagcloud (Intersection) ?