CNOT4 and CNOT8

Number of citations of the paper that reports this interaction (PMID 10637334)
50

Data Source:
HPRD (two hybrid)

		CNOT4	CNOT8
Gene Name		CCR4-NOT transcription complex, subunit 4	CCR4-NOT transcription complex, subunit 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol CCR4-NOT Complex	Intracellular Nucleus Cytosol CCR4-NOT Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly(A) RNA Binding	3'-5'-exoribonuclease Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Gene Expression Protein Autoubiquitination	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CNOT1 CNOT8 EP300 KDM5C UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	9 interactors: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2
Entrez ID		4850	9337
HPRD ID		05369	07225
Ensembl ID		ENSG00000080802	ENSG00000155508
Uniprot IDs		O95628	B0AZS3 B7Z8R1 Q9UFF9
PDB IDs		1E4U 1UR6
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Macromolecule Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Protein Modification Process Protein K63-linked Ubiquitination Toll-like Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxygen Levels Proteasomal Protein Catabolic Process Catabolic Process Protein Monoubiquitination Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression Regulation Of Innate Immune Response Cellular Response To Stress Proteolysis Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transcription, DNA-templated Histone Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Metabolic Process Histone Modification Cellular Response To Organic Substance Innate Immune Response	Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nuclear-transcribed MRNA Catabolic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process RNA Catabolic Process Gene Silencing By RNA Regulation Of Translation Gene Silencing Regulation Of Stem Cell Maintenance Positive Regulation Of Organelle Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Processing Regulation Of Cell Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Regulation Of Gene Expression Trophectodermal Cell Differentiation Positive Regulation Of MRNA Catabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Gene Silencing By MiRNA Blastocyst Formation Posttranscriptional Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Component Biogenesis Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Catabolic Process RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Myeloid Cell Differentiation
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