CNOT8 and BTG1

Number of citations of the paper that reports this interaction (PMID 11136725)
30

Data Source:
BioGRID (two hybrid, two hybrid, pull down, two hybrid)
HPRD (in vitro)

		CNOT8	BTG1
Gene Name		CCR4-NOT transcription complex, subunit 8	B-cell translocation gene 1, anti-proliferative
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytosol CCR4-NOT Complex	Nucleus Cytoplasm
	Molecular Function	3'-5'-exoribonuclease Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	Transcription Cofactor Activity Protein Binding Enzyme Binding Kinase Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Fibroblast Apoptotic Process
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS			Heart failure ( 20445134)
Protein-Protein Interactions		9 interactors: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	12 interactors: CCNA2 CNOT7 CNOT8 HOXB9 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6
Entrez ID		9337	694
HPRD ID		07225	15912
Ensembl ID		ENSG00000155508
Uniprot IDs		B0AZS3 B7Z8R1 Q9UFF9	P62324 Q6IBC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nuclear-transcribed MRNA Catabolic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process RNA Catabolic Process Gene Silencing By RNA Regulation Of Translation Gene Silencing Regulation Of Stem Cell Maintenance Positive Regulation Of Organelle Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Processing Regulation Of Cell Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Regulation Of Gene Expression Trophectodermal Cell Differentiation Positive Regulation Of MRNA Catabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Gene Silencing By MiRNA Blastocyst Formation Posttranscriptional Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Component Biogenesis Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Catabolic Process RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Myeloid Cell Differentiation	Female Courtship Behavior Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Female Receptivity Positive Regulation Of Cellular Metabolic Process Female Mating Behavior Type I Pneumocyte Differentiation Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated G2/M Transition Of Mitotic Cell Cycle Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Proliferation Regulation Of RNA Metabolic Process Transcription, DNA-templated Hormone-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Response To Steroid Hormone Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Transcription Initiation From RNA Polymerase II Promoter Mating Behavior Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Stimulus Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing By MiRNA DNA-templated Transcription, Initiation Posttranscriptional Gene Silencing Mating Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Lung Epithelial Cell Differentiation Regulation Of Translation Respiratory System Development RNA Metabolic Process Lung Cell Differentiation Lung Epithelium Development Gene Silencing By RNA
Tagcloud ?			accompanied achn adjacent bcell biopsies biopsy blotting empty endoscopic fraction g0 immediately indicator kidney lebtg1 leempty lentivirus lymphoma metalloproteinase proportion regulator respect serve stably transfected utilizing vectortransfected vs
Tagcloud (Difference) ?			accompanied achn adjacent bcell biopsies biopsy blotting empty endoscopic fraction g0 immediately indicator kidney lebtg1 leempty lentivirus lymphoma metalloproteinase proportion regulator respect serve stably transfected utilizing vectortransfected vs
Tagcloud (Intersection) ?