NFKBIL1 and CASP10

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NFKBIL1	CASP10
Gene Name		nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1	caspase 10, apoptosis-related cysteine peptidase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Intermediate Filament Cytoskeleton	Cytoplasm Cytosol Plasma Membrane CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Cellular Response To Lipopolysaccharide	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Apoptotic Signaling Pathway
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAIL signaling Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) Neonatal lupus ( 20662065)
Protein-Protein Interactions		4 interactors: ADIPOR1 C2orf88 CASP10 CLEC18C	30 interactors: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		4795	843
HPRD ID		07043	03458
Ensembl ID		ENSG00000204498	ENSG00000003400
Uniprot IDs		A8K778 Q5STV6 Q9UBC1	Q92851
PDB IDs
Enriched GO Terms of Interacting Partners?		Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Cellular Response To Leptin Stimulus Response To Leptin Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of JAK-STAT Cascade Regulation Of Insulin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fatty Acid Oxidation Lipid Oxidation Regulation Of Cellular Response To Insulin Stimulus Regulation Of JAK-STAT Cascade Hormone-mediated Signaling Pathway Negative Regulation Of Cell Growth Regulation Of Signal Transduction	Apoptotic Process Programmed Cell Death Cell Death Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Execution Phase Of Apoptosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Protein Processing Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Apoptotic Process Intracellular Signal Transduction Proteolysis Regulation Of Necroptotic Process Positive Regulation Of Neuron Apoptotic Process Neuron Death Regulation Of Cellular Protein Metabolic Process Hepatocyte Apoptotic Process Signaling Positive Regulation Of Neuron Death
Tagcloud ?		6p21 correspond cpg distant dnase dysregulation enhancer exon hek293t hypersensitive intergenic island jurkat k4 localize locus lta ltb lymphoblastoid lymphotoxin peaks polypeptide spanning stimulatory tri u937 upstream usf	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Difference) ?		6p21 correspond cpg distant dnase dysregulation enhancer exon hek293t hypersensitive intergenic island jurkat k4 localize locus lta ltb lymphoblastoid lymphotoxin peaks polypeptide spanning stimulatory tri u937 upstream usf	arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn
Tagcloud (Intersection) ?