NFKBIE and PPP6C

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vitro, in vivo)

		NFKBIE	PPP6C
Gene Name		nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	protein phosphatase 6, catalytic subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Protein Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	D-serine Transport Cytoplasmic Sequestering Of Transcription Factor	G1/S Transition Of Mitotic Cell Cycle Protein Dephosphorylation
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of NF-kappaB in B cells Adaptive Immune System
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 22446963 23028356)
Protein-Protein Interactions		15 interactors: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1	5 interactors: IGBP1 NFKBIE PRKDC TGFBR1 TIPRL
Entrez ID		4794	5537
HPRD ID		05181	02141
Ensembl ID		ENSG00000146232	ENSG00000119414
Uniprot IDs		O00221 Q96F31	O00743
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Inflammatory Response Negative Regulation Of Transcription From RNA Polymerase II Promoter NIK/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Interleukin-12 Production Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Defense Response Negative Regulation Of Biosynthetic Process Regulation Of Cytokine Production Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Cytokine Production Response To Cytokine Signaling Response To Organic Substance Positive Regulation Of Metabolic Process Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of MiRNA Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cytokine Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune System Process Regulation Of Protein Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-12 Biosynthetic Process Cellular Response To Nicotine Cellular Response To Stimulus	Regulation Of Phosphorus Metabolic Process Negative Regulation Of Dephosphorylation Cell Activation Peptidyl-serine Phosphorylation Regulation Of Dephosphorylation Negative Regulation Of Protein Phosphatase Type 2A Activity D-serine Transport DNA Damage Checkpoint B Cell Activation Regulation Of Protein Import Into Nucleus Regulation Of Protein Phosphatase Type 2A Activity Apoptotic Process Regulation Of Protein Localization To Nucleus Programmed Cell Death Regulation Of Nucleocytoplasmic Transport Cell Cycle Process Cell Death Death Cell Cycle Checkpoint Pro-B Cell Differentiation Anterior/posterior Pattern Specification Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Protein Dephosphorylation Regulation Of Intracellular Protein Transport Cell Fate Commitment Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Cell Cycle Immunoglobulin V(D)J Recombination Parathyroid Gland Development Negative Regulation Of Phosphoprotein Phosphatase Activity T Cell Receptor V(D)J Recombination B Cell Lineage Commitment Regulation Of Apoptotic Process Lymphoid Progenitor Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Endothelial Cell Activation Positive Regulation Of Gene Expression Regulation Of Cell Death Negative Regulation Of Phosphorylation Negative Regulation Of Hydrolase Activity Positive Regulation Of Cellular Biosynthetic Process Ectopic Germ Cell Programmed Cell Death Pathway-restricted SMAD Protein Phosphorylation Lymphocyte Activation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Microtubule-based Movement Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Regulation Of SMAD Protein Import Into Nucleus
Tagcloud ?		1980s a20 acquire bearing budding ccl17 ccl22 cd23 cd40 cd40l cd80 chemoattractant chronically costimulatory cytidine deaminase humoral hypergammaglobulinemia issued lymphotoxin map2k1 messengers nfkb1 productively tnip1 tonsillar traf1 virions	actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras pik3r4 prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557
Tagcloud (Difference) ?		1980s a20 acquire bearing budding ccl17 ccl22 cd23 cd40 cd40l cd80 chemoattractant chronically costimulatory cytidine deaminase humoral hypergammaglobulinemia issued lymphotoxin map2k1 messengers nfkb1 productively tnip1 tonsillar traf1 virions	actionable adamts18 col1a1 d816 dgki epha4 epha7 g12 g13 gna11 gnaq gucy2c k642 kalrn l576 melanomas mined ngs nras pik3r4 prkaa2 q209 q61 stk31 taf1l trpm6 v559 v600 w557
Tagcloud (Intersection) ?