MYL2 and USP6

Number of citations of the paper that reports this interaction (PMID 16555005)
2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MYL2	USP6
Gene Name		myosin, light chain 2, regulatory, cardiac, slow	ubiquitin specific peptidase 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band	Cytoplasm Lysosome Plasma Membrane Recycling Endosome
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding	Nucleic Acid Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Rab GTPase Activator Activity Protein Binding Calmodulin Binding
	Biological Process	Regulation Of Striated Muscle Contraction Post-embryonic Development Muscle Filament Sliding Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Fiber Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Cellular Protein Modification Process Protein Deubiquitination Positive Regulation Of Rab GTPase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Proteasomal Protein Catabolic Process
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) HDL cholesterol ( 21909109)
Protein-Protein Interactions		9 interactors: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PPP1R12C TRIM63 USP6	9 interactors: ANKRD44 APP ATXN7L3 CDC42 EXOSC8 MDFI MYL2 RAB33B RAC1
Entrez ID		4633	9098
HPRD ID		01181	06827
Ensembl ID		ENSG00000111245	ENSG00000129204
Uniprot IDs		P10916 Q6IB42	P35125
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Adaptation ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy RRNA Pseudouridine Synthesis Ubiquitin-dependent Endocytosis ERBB2 Signaling Pathway Protein Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Spongiotrophoblast Differentiation Cellular Protein Modification Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Skeletal Muscle Atrophy Non-canonical Wnt Signaling Pathway Via MAPK Cascade Striated Muscle Atrophy Muscle Atrophy Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Execution Phase Of Apoptosis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Viral Budding Proteasomal Protein Catabolic Process Muscle System Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Neuronal Ion Channel Clustering Nuclear Migration Negative Regulation Of Actin Filament Bundle Assembly	Organ Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Binding Regulation Of Kinase Activity Organ Development Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Heart Contraction Positive Regulation Of DNA Replication Axon Guidance Negative Regulation Of Transport Regulation Of Protein Phosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Cellular Protein Metabolic Process Blood Coagulation Hemostasis Regulation Of Intracellular Transport Regulation Of ERBB Signaling Pathway Negative Regulation Of Constitutive Secretory Pathway Muscle Cell Fate Specification Regulation Of Synapse Structure Or Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Ephrin Receptor Signaling Pathway Cellular Localization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Axonogenesis System Development Cellular Protein Localization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Cell Projection Assembly Positive Regulation Of JNK Cascade Positive Regulation Of Cell-substrate Adhesion Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Regulation Of DNA Replication Vesicle-mediated Transport Wound Healing
Tagcloud ?		calcium carrier cav1 channel codes computational evidences gla herein knockdown messenger mgp mrfs mscs muscle myh3 myogenesis myogenic myosin myotube retinol satellite signifies t4 thyroxin transportation transthyretin ttr voltage	abc aneurysmal attenuates atypical augmented autoimmunity canonical classical cyst distinguishing dysregulated ikappab ikk ikkalpha ikkbeta ikkgamma involve nemo nih3t3 overexpressed precipitates s536 translocated tre17 tumorigenic ubiquitinating uncover unexpected
Tagcloud (Difference) ?		calcium carrier cav1 channel codes computational evidences gla herein knockdown messenger mgp mrfs mscs muscle myh3 myogenesis myogenic myosin myotube retinol satellite signifies t4 thyroxin transportation transthyretin ttr voltage	abc aneurysmal attenuates atypical augmented autoimmunity canonical classical cyst distinguishing dysregulated ikappab ikk ikkalpha ikkbeta ikkgamma involve nemo nih3t3 overexpressed precipitates s536 translocated tre17 tumorigenic ubiquitinating uncover unexpected
Tagcloud (Intersection) ?