MYL2 and PPP1R12C

Number of citations of the paper that reports this interaction (PMID 11399775)
36

Data Source:
HPRD (in vivo, in vitro)

		MYL2	PPP1R12C
Gene Name		myosin, light chain 2, regulatory, cardiac, slow	protein phosphatase 1, regulatory subunit 12C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band	Cytoplasm
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding	Protein Binding
	Biological Process	Regulation Of Striated Muscle Contraction Post-embryonic Development Muscle Filament Sliding Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Fiber Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS		Alcohol consumption ( 21270382) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) HDL cholesterol ( 21909109)
Protein-Protein Interactions		9 interactors: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PPP1R12C TRIM63 USP6	11 interactors: ATXN7 C1orf109 CACNA1A CDC42BPA IL16 MPRIP MYL2 PAFAH1B2 PPP1CB RBM17 SMAD3
Entrez ID		4633	54776
HPRD ID		01181	11452
Ensembl ID		ENSG00000111245	ENSG00000125503
Uniprot IDs		P10916 Q6IB42	B4DME2 Q9BZL4
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Adaptation ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy RRNA Pseudouridine Synthesis Ubiquitin-dependent Endocytosis ERBB2 Signaling Pathway Protein Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Spongiotrophoblast Differentiation Cellular Protein Modification Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Skeletal Muscle Atrophy Non-canonical Wnt Signaling Pathway Via MAPK Cascade Striated Muscle Atrophy Muscle Atrophy Clustering Of Voltage-gated Sodium Channels Negative Regulation Of Execution Phase Of Apoptosis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Viral Budding Proteasomal Protein Catabolic Process Muscle System Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Neuronal Ion Channel Clustering Nuclear Migration Negative Regulation Of Actin Filament Bundle Assembly	Positive Regulation Of Positive Chemotaxis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cerebellar Molecular Layer Development Positive Regulation Of Transforming Growth Factor Beta3 Production Muscle Cell Fate Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Chemotaxis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Vestibular Nucleus Development Actomyosin Structure Organization Positive Regulation Of Behavior Regulation Of Chemotaxis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Evasion Or Tolerance Of Host Defenses By Virus Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Gamma-aminobutyric Acid Secretion Negative Regulation Of Cell Growth Regulation Of Extracellular Matrix Assembly Regulation Of Acetylcholine Secretion, Neurotransmission Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Rhythmic Synaptic Transmission Primary MiRNA Processing Response To Transforming Growth Factor Beta Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Glycogen Catabolic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Heart Morphogenesis Response To External Stimulus Cellular Chloride Ion Homeostasis Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Transforming Growth Factor Beta2 Production Chloride Ion Homeostasis Transdifferentiation Gamma-aminobutyric Acid Transport Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth Lipid Catabolic Process Positive Regulation Of Catenin Import Into Nucleus Negative Regulation Of Hormone Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Pons Development
Tagcloud ?		calcium carrier cav1 channel codes computational evidences gla herein knockdown messenger mgp mrfs mscs muscle myh3 myogenesis myogenic myosin myotube retinol satellite signifies t4 thyroxin transportation transthyretin ttr voltage
Tagcloud (Difference) ?		calcium carrier cav1 channel codes computational evidences gla herein knockdown messenger mgp mrfs mscs muscle myh3 myogenesis myogenic myosin myotube retinol satellite signifies t4 thyroxin transportation transthyretin ttr voltage
Tagcloud (Intersection) ?