SERPINC1 and SDC2

Number of citations of the paper that reports this interaction (PMID 1315572)
3

Data Source:
HPRD (in vivo)

		SERPINC1	SDC2
Gene Name		serpin peptidase inhibitor, clade C (antithrombin), member 1	syndecan 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Golgi Lumen Plasma Membrane Integral Component Of Membrane Neuronal Cell Body Lysosomal Lumen Synapse
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding	Protein Binding PDZ Domain Binding
	Biological Process	Response To Nutrient Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Inflammatory Response Regulation Of Blood Coagulation, Intrinsic Pathway	Retinoid Metabolic Process Response To Hypoxia Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Response To Caffeine Wound Healing Small Molecule Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways		Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism EPHB-mediated forward signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D EPH-Ephrin signaling A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs		Ardeparin Fondaparinux sodium Heparin Enoxaparin Alpha-D-Mannose N-Formylmethionine Sulodexide Dalteparin Tinzaparin Nadroparin
Diseases
GWAS
Protein-Protein Interactions		5 interactors: F2 KLK2 KLK6 PLG SDC2	26 interactors: BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF KAL1 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		462	6383
HPRD ID		00122	00803
Ensembl ID		ENSG00000117601	ENSG00000169439
Uniprot IDs		P01008	E9PBI9 P34741
PDB IDs		1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Tissue Regeneration Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurogenesis Regulation Of Wound Healing Regulation Of Cell Development Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Mononuclear Cell Migration Platelet Activation Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Leukocyte Migration Locomotion Developmental Growth Cell Differentiation Response To Stress Protein Autoprocessing Movement Of Cell Or Subcellular Component Regulation Of Neuron Projection Development Generation Of Neurons Regulation Of Cell Differentiation Peptidyl-glutamic Acid Carboxylation Blood Coagulation Neurogenesis Hemostasis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Regulation Of Cell Morphogenesis Catabolic Process Regulation Of Cell Projection Organization Amyloid Precursor Protein Metabolic Process Growth	Regulation Of Body Fluid Levels Platelet Activation Wound Healing Response To Wounding Blood Coagulation Hemostasis Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Epithelial Cell Proliferation Cell Activation Regulation Of Angiogenesis Regulation Of Cell Migration Multicellular Organismal Development Regulation Of Epithelial Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Cell Proliferation Response To Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Locomotion Positive Regulation Of Signal Transduction System Development Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endothelial Cell Migration Anatomical Structure Development Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stress Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration Cell Development Histone H3-T6 Phosphorylation
Tagcloud ?		antithrombin autosomal buccal budapest cct clade codon cover deep deficiency exons giving heterozygous inherited malay malaysia malaysian mucosal ncbi peptidase swabs thr thrombin thromboembolism thrombosis vte woman	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Difference) ?		antithrombin autosomal buccal budapest cct clade codon cover deep deficiency exons giving heterozygous inherited malay malaysia malaysian mucosal ncbi peptidase swabs thr thrombin thromboembolism thrombosis vte woman	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Intersection) ?