SERPINC1

Gene Name		serpin peptidase inhibitor, clade C (antithrombin), member 1
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding
	Biological Process	Response To Nutrient Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Inflammatory Response Regulation Of Blood Coagulation, Intrinsic Pathway
Pathways		Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Ardeparin Fondaparinux sodium Heparin Enoxaparin Alpha-D-Mannose N-Formylmethionine Sulodexide Dalteparin Tinzaparin Nadroparin
Diseases
GWAS
Protein-protein Interactions		5 interactors: F2 KLK2 KLK6 PLG SDC2
Entrez ID		462
HPRD ID		00122
Ensembl ID		ENSG00000117601
Uniprot IDs		P01008
PDB IDs		1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibrinolysis Wound Healing Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Tissue Regeneration Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Proteolysis Extracellular Matrix Disassembly Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurogenesis Regulation Of Wound Healing Regulation Of Cell Development Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Mononuclear Cell Migration Platelet Activation Protein Metabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Leukocyte Migration Locomotion Developmental Growth Cell Differentiation Response To Stress Protein Autoprocessing Movement Of Cell Or Subcellular Component Regulation Of Neuron Projection Development Generation Of Neurons Regulation Of Cell Differentiation Peptidyl-glutamic Acid Carboxylation Blood Coagulation Neurogenesis Hemostasis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Platelet Activation Regulation Of Cell Morphogenesis Catabolic Process Regulation Of Cell Projection Organization Amyloid Precursor Protein Metabolic Process Growth
Tagcloud ?		antithrombin autosomal buccal budapest cct clade codon cover deep deficiency exons giving heterozygous inherited malay malaysia malaysian mucosal ncbi peptidase swabs thr thrombin thromboembolism thrombosis vte woman