MX1 and TRPC3

Number of citations of the paper that reports this interaction (PMID 15757897)
7

Data Source:
HPRD (in vivo, in vitro)

		MX1	TRPC3
Gene Name		MX dynamin-like GTPase 1	transient receptor potential cation channel, subfamily C, member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Nuclear Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Apoptotic Process Defense Response Signal Transduction Metabolic Process Response To Virus Cytokine-mediated Signaling Pathway Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Type I Interferon Signaling Pathway	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACTB APP BLM CAB39L DAXX FANCA PIAS1 SIAH1 SP100 SUMO1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBB	20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		4599	7222
HPRD ID		00919	15999
Ensembl ID		ENSG00000157601	ENSG00000138741
Uniprot IDs		P20591	J3QTB0 Q13507
PDB IDs		3LJB 3SZR 3ZYS
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Calcium Ion Transmembrane Transport Neuron Development Cell Morphogenesis Movement Of Cell Or Subcellular Component Response To Stimulus Neuron Differentiation Cell Projection Organization Calcium Ion Transport Locomotion Platelet Activation Response To Stress Generation Of Neurons Neurogenesis Cell Development Response To External Stimulus Regulation Of Body Fluid Levels Cell Activation Nervous System Development Blood Coagulation Hemostasis Intracellular Receptor Signaling Pathway Anatomical Structure Development Anatomical Structure Morphogenesis Innate Immune Response Metal Ion Transport System Development Cell Differentiation Cation Transmembrane Transport Regulation Of Binding Positive Regulation Of Calcium Ion Transport Developmental Process Wound Healing Multicellular Organismal Development Interferon-gamma-mediated Signaling Pathway Response To Wounding Cation Transport Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cellular Response To Interferon-gamma Protein Sumoylation	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol
Tagcloud ?		antiproliferative apl appear autoantigen bodies contain disruption elucidation fusion harbors ifn ifns inactivation interferons labelled leukemogenesis link mediate mediator microspeckles nbs ndp52 pml promyelocytic rxrs sequestration sp100 speckles suppressing	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Difference) ?		antiproliferative apl appear autoantigen bodies contain disruption elucidation fusion harbors ifn ifns inactivation interferons labelled leukemogenesis link mediate mediator microspeckles nbs ndp52 pml promyelocytic rxrs sequestration sp100 speckles suppressing	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Intersection) ?