ASGR1 and ASGR2

Number of citations of the paper that reports this interaction (PMID 2834401)
13

Data Source:
HPRD (in vivo)

		ASGR1	ASGR2
Gene Name		asialoglycoprotein receptor 1	asialoglycoprotein receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Integral Component Of Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Protein Homodimerization Activity Metal Ion Binding	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Receptor-mediated Endocytosis Cellular Response To Extracellular Stimulus	Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Glycoprotein Metabolic Process Bone Mineralization Regulation Of Protein Stability Lipid Homeostasis
Pathways
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		12 interactors: APP ASGR2 CERS2 CLEC4G DHFR HIVEP1 HSP90AA1 HSP90B1 NLK RBBP6 TG VKORC1	7 interactors: ASGR1 CERS2 F8 GLUD1 HES1 MROH5 VKORC1
Entrez ID		432	433
HPRD ID		00151	00152
Ensembl ID		ENSG00000141505	ENSG00000161944
Uniprot IDs		P07306 Q6FGQ5	P07307 Q7Z4G9
PDB IDs		1DV8
Enriched GO Terms of Interacting Partners?		Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Metabolic Process Regulation Of Nitric-oxide Synthase Activity Endocytosis Receptor-mediated Endocytosis Regulation Of Oxidoreductase Activity Actin Rod Assembly Synaptic Growth At Neuromuscular Junction Reactive Oxygen Species Metabolic Process Vitamin Metabolic Process Collateral Sprouting In Absence Of Injury Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Serine Phosphorylation Of STAT3 Protein Sequestering Of Calcium Ion Collateral Sprouting Axon Midline Choice Point Recognition Serine Phosphorylation Of STAT Protein Small Molecule Metabolic Process Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Iodide Transport Axon Choice Point Recognition Vitamin K Metabolic Process Vesicle-mediated Transport	Midbrain Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Inhibition Of Neuroepithelial Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Auditory Receptor Cell Fate Determination Trochlear Nerve Development Ascending Aorta Morphogenesis Positive Regulation Of Mitotic Cell Cycle, Embryonic Oculomotor Nerve Development Regulation Of Pro-B Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation STAT Protein Import Into Nucleus Glutamate Catabolic Process Regulation Of Forebrain Neuron Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Timing Of Neuron Differentiation Forebrain Radial Glial Cell Differentiation Vitamin K Metabolic Process Comma-shaped Body Morphogenesis Common Bile Duct Development Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Renal Interstitial Fibroblast Development Glutamate Biosynthetic Process S-shaped Body Morphogenesis Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Fate Determination Auditory Receptor Cell Fate Commitment Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Astrocyte Differentiation Radial Glial Cell Differentiation Vascular Smooth Muscle Cell Development Negative Regulation Of Glial Cell Proliferation Regulation Of Secondary Heart Field Cardioblast Proliferation Dicarboxylic Acid Catabolic Process Metanephric Tubule Morphogenesis Peptidyl-glutamic Acid Carboxylation Midbrain-hindbrain Boundary Development Adenohypophysis Development Blood Coagulation, Intrinsic Pathway Oxidation-reduction Process Blood Coagulation Metanephric Nephron Tubule Development
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