ASGR2 and CERS2

Number of citations of the paper that reports this interaction (PMID 11543633)
7

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ASGR2	CERS2
Gene Name		asialoglycoprotein receptor 2	ceramide synthase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding	DNA Binding Protein Binding Sphingosine N-acyltransferase Activity
	Biological Process	Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Glycoprotein Metabolic Process Bone Mineralization Regulation Of Protein Stability Lipid Homeostasis	Sphingolipid Metabolic Process Sphingolipid Biosynthetic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS			Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		7 interactors: ASGR1 CERS2 F8 GLUD1 HES1 MROH5 VKORC1	9 interactors: ASGR1 ASGR2 ATP6V0C HSP90AA1 PEX6 SLC19A2 SLC22A1 SLC39A1 TMBIM6
Entrez ID		433	29956
HPRD ID		00152	06080
Ensembl ID		ENSG00000161944	ENSG00000143418
Uniprot IDs		P07307 Q7Z4G9	Q96G23
PDB IDs
Enriched GO Terms of Interacting Partners?		Midbrain Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Inhibition Of Neuroepithelial Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Auditory Receptor Cell Fate Determination Trochlear Nerve Development Ascending Aorta Morphogenesis Positive Regulation Of Mitotic Cell Cycle, Embryonic Oculomotor Nerve Development Regulation Of Pro-B Cell Differentiation Regulation Of Auditory Receptor Cell Differentiation STAT Protein Import Into Nucleus Glutamate Catabolic Process Regulation Of Forebrain Neuron Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Timing Of Neuron Differentiation Forebrain Radial Glial Cell Differentiation Vitamin K Metabolic Process Comma-shaped Body Morphogenesis Common Bile Duct Development Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Renal Interstitial Fibroblast Development Glutamate Biosynthetic Process S-shaped Body Morphogenesis Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Neuron Fate Determination Auditory Receptor Cell Fate Commitment Negative Regulation Of Epidermal Cell Differentiation Positive Regulation Of Astrocyte Differentiation Radial Glial Cell Differentiation Vascular Smooth Muscle Cell Development Negative Regulation Of Glial Cell Proliferation Regulation Of Secondary Heart Field Cardioblast Proliferation Dicarboxylic Acid Catabolic Process Metanephric Tubule Morphogenesis Peptidyl-glutamic Acid Carboxylation Midbrain-hindbrain Boundary Development Adenohypophysis Development Blood Coagulation, Intrinsic Pathway Oxidation-reduction Process Blood Coagulation Metanephric Nephron Tubule Development	Transmembrane Transport Transport Drug Transmembrane Transport Drug Transport Intracellular Protein Transmembrane Transport Protein Transmembrane Transport Receptor-mediated Endocytosis Epinephrine Transport Response To Unfolded Protein Protein Import Into Peroxisome Matrix, Translocation Acetate Ester Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Protein Stability Protein Import Into Mitochondrial Outer Membrane Norepinephrine Transport Protein Import Endocytosis Thiamine Transmembrane Transport Thiamine Transport Thiamine-containing Compound Metabolic Process Ion Transport Folic Acid Transport Chemical Homeostasis Dopamine Transport Cation Transmembrane Transport Chaperone-mediated Protein Complex Assembly Protein Import Into Peroxisome Matrix Pyrimidine-containing Compound Transmembrane Transport Quaternary Ammonium Group Transport Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Protein Refolding Vitamin Transmembrane Transport Cation Transport Zinc Ion Transmembrane Transport Cellular Metal Ion Homeostasis Monoamine Transport Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Response To Stimulus Protein Targeting Ion Transmembrane Transport Nitric Oxide Metabolic Process Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Cation Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Cellular Response To Heat Cellular Ion Homeostasis Reactive Nitrogen Species Metabolic Process Posttranscriptional Regulation Of Gene Expression
Tagcloud ?			17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Difference) ?			17beta ceramide ceramides cers4 cers5 cers6 clarify constructs dimerization erbeta estradiol fos fulvestrant fumonisin gper1 investigating lengths luc luciferase mcf pathophysiological plasmids posttranscriptional processess promoters sphingolipid synthases utr
Tagcloud (Intersection) ?