MMP9 and THBS1

Number of citations of the paper that reports this interaction (PMID 11606713)
92

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		MMP9	THBS1
Gene Name		matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	thrombospondin 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Collagen Binding Zinc Ion Binding Identical Protein Binding	Phosphatidylserine Binding Glycoprotein Binding Fibronectin Binding Integrin Binding Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Identical Protein Binding Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Fibrinogen Binding Collagen V Binding
	Biological Process	Skeletal System Development Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Receptor Binding Negative Regulation Of Cation Channel Activity	Activation Of MAPK Activity Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Platelet Degranulation Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Outflow Tract Morphogenesis Endocardial Cushion Development Growth Plate Cartilage Development Protein O-linked Glycosylation Immune Response Response To Unfolded Protein Cell Cycle Arrest Cell Adhesion Blood Coagulation Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Peptide Cross-linking Platelet Activation Positive Regulation Of Blood Coagulation Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of CGMP Metabolic Process Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-12 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Protein O-linked Fucosylation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by SCF-KIT EPH-ephrin mediated repulsion of cells Axon guidance Collagen formation Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Signaling by PDGF Post-translational protein modification Non-integrin membrane-ECM interactions Platelet degranulation O-glycosylation of TSR domain-containing proteins O-linked glycosylation Syndecan interactions Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs		Marimastat Minocycline Captopril Glucosamine 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		32 interactors: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFB1 THBS1 THBS2 TIMP3	39 interactors: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B
Entrez ID		4318	7057
HPRD ID		00387	01765
Ensembl ID		ENSG00000100985
Uniprot IDs		P14780	P07996
PDB IDs		1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA	1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Blood Vessel Development Vasculature Development Catabolic Process Regulation Of Body Fluid Levels Response To External Stimulus Chemotaxis Cell Migration Positive Regulation Of Chemotaxis Cell Motility Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Blood Coagulation Negative Regulation Of Peptidase Activity Inflammatory Response Hemostasis Defense Response Cardiovascular System Development Positive Regulation Of Leukocyte Migration Regulation Of Behavior Platelet Activation Response To Organic Substance Positive Regulation Of Cell Migration Response To Cytokine Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Protein Processing Regulation Of Leukocyte Migration Immune Response Leukocyte Migration Regulation Of Endopeptidase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Hydrolase Activity	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Platelet Degranulation Blood Coagulation Hemostasis Vesicle-mediated Transport Collagen Catabolic Process Regulation Of Locomotion Response To External Stimulus Collagen Metabolic Process Regulation Of Body Fluid Levels Cardiovascular System Development Regulation Of Cell Migration Multicellular Organismal Macromolecule Metabolic Process Locomotion Multicellular Organismal Metabolic Process Regulation Of Cell Motility Blood Vessel Development Vasculature Development Response To Stimulus Regulation Of Cellular Component Movement Tissue Development Response To Stress Leukocyte Migration Response To Organic Substance Movement Of Cell Or Subcellular Component Negative Regulation Of Wound Healing Endocytosis Cell Migration Regulation Of Wound Healing Cell Activation Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Anatomical Structure Morphogenesis Exocytosis Positive Regulation Of Cellular Component Movement Immune System Process Positive Regulation Of Locomotion Regulation Of Blood Coagulation Multicellular Organismal Development Negative Regulation Of Blood Coagulation Anatomical Structure Development Negative Regulation Of Coagulation System Development
Tagcloud ?		alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Difference) ?		alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth	bag1 bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs2
Tagcloud (Intersection) ?