MMP9 and MMP10

Number of citations of the paper that reports this interaction (PMID 9578462)
14

Data Source:
HPRD (in vitro)

		MMP9	MMP10
Gene Name		matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	matrix metallopeptidase 10 (stromelysin 2)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Collagen Binding Zinc Ion Binding Identical Protein Binding	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Receptor Binding Negative Regulation Of Cation Channel Activity	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process
Pathways		Signaling by SCF-KIT EPH-ephrin mediated repulsion of cells Axon guidance Collagen formation Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Marimastat Minocycline Captopril Glucosamine 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Multiple sclerosis ( 23412934) Prostate cancer ( 23535732)
Protein-Protein Interactions		32 interactors: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFB1 THBS1 THBS2 TIMP3	3 interactors: BCAN HAPLN1 MMP9
Entrez ID		4318	4319
HPRD ID		00387	01704
Ensembl ID		ENSG00000100985	ENSG00000166670
Uniprot IDs		P14780	P09238
PDB IDs		1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA	1Q3A 3V96
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Blood Vessel Development Vasculature Development Catabolic Process Regulation Of Body Fluid Levels Response To External Stimulus Chemotaxis Cell Migration Positive Regulation Of Chemotaxis Cell Motility Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Blood Coagulation Negative Regulation Of Peptidase Activity Inflammatory Response Hemostasis Defense Response Cardiovascular System Development Positive Regulation Of Leukocyte Migration Regulation Of Behavior Platelet Activation Response To Organic Substance Positive Regulation Of Cell Migration Response To Cytokine Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Protein Processing Regulation Of Leukocyte Migration Immune Response Leukocyte Migration Regulation Of Endopeptidase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Hydrolase Activity	Extracellular Matrix Organization Extracellular Structure Organization Skeletal System Development Extracellular Matrix Disassembly Positive Regulation Of Receptor Binding Positive Regulation Of Keratinocyte Migration Nervous System Development Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Cation Channel Activity Macrophage Differentiation Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Endodermal Cell Differentiation Central Nervous System Development Negative Regulation Of Transporter Activity System Development Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cell Adhesion Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Binding Hippocampus Development Anatomical Structure Development Regulation Of Cation Channel Activity Embryo Implantation Collagen Metabolic Process Positive Regulation Of Epithelial Cell Migration Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Negative Regulation Of Ion Transport Limbic System Development Ephrin Receptor Signaling Pathway Glycosaminoglycan Biosynthetic Process Developmental Process Proteoglycan Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of Binding Catabolic Process Formation Of Primary Germ Layer Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration
Tagcloud ?		alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth	affecting bad biochemical blotting cadherin compartments concomitant conveys cxcr4 delay elisa extracellular herein invasion jnk matrix mcf7 mek obtain overexpressing ras reporter semi sirna snail sp1 stats tlmp2 valuable
Tagcloud (Difference) ?		alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth	affecting bad biochemical blotting cadherin compartments concomitant conveys cxcr4 delay elisa extracellular herein invasion jnk matrix mcf7 mek obtain overexpressing ras reporter semi sirna snail sp1 stats tlmp2 valuable
Tagcloud (Intersection) ?