KITLG and CSF2

Number of citations of the paper that reports this interaction (PMID 12421569)
2

Data Source:
HPRD (in vivo)

		KITLG	CSF2
Gene Name		KIT ligand	colony stimulating factor 2 (granulocyte-macrophage)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Melanocyte Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Embryonic Placenta Development Immune Response Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Interleukin-23 Production Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Cytolysis Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS		Blond vs. brown hair color ( 17952075) Hair color ( 23548203) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 23666239 23666240)	Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		8 interactors: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1	7 interactors: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 SDC2
Entrez ID		4254	1437
HPRD ID		01698	00734
Ensembl ID			ENSG00000164400
Uniprot IDs		P21583	P04141
PDB IDs		1EXZ 1SCF 2E9W	1CSG 2GMF 3CXE
Enriched GO Terms of Interacting Partners?		Erythropoietin-mediated Signaling Pathway Mast Cell Differentiation Cellular Response To Erythropoietin Mast Cell Chemotaxis Leukocyte Differentiation Myeloid Leukocyte Differentiation Cytokine Production Leukocyte Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Hemopoiesis Mast Cell Degranulation Cell Activation Mast Cell Mediated Immunity Fc-epsilon Receptor Signaling Pathway Immune System Development Embryonic Hemopoiesis Lysosome Localization Lymphocyte Differentiation Mast Cell Activation Myeloid Cell Differentiation Fc Receptor Signaling Pathway Leukocyte Degranulation Positive Regulation Of Cell Proliferation Organ Development Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulated Secretory Pathway Cellular Response To Organic Substance Positive Regulation Of JAK-STAT Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Developmental Process Lymphocyte Activation Immune System Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Error-free Postreplication DNA Repair Mast Cell Proliferation Interleukin-1 Beta Biosynthetic Process Immune Response-regulating Signaling Pathway Regulation Of JAK-STAT Cascade Embryonic Organ Development Reproductive Structure Development Reproductive System Development Immune Response Regulation Of Immune System Process Leukocyte Chemotaxis Response To Organic Substance T Cell Receptor Signaling Pathway System Development Kit Signaling Pathway	Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Cytokine-mediated Signaling Pathway Response To Organic Substance Cellular Response To Cytokine Stimulus Interleukin-5-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Defense Response To Nematode Cellular Response To Organic Substance Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Mast Cell Apoptotic Process Somite Specification Positive Regulation Of Mast Cell Proliferation Response To Nematode Positive Regulation Of Melanocyte Differentiation Regulation Of Melanocyte Differentiation Positive Regulation Of Pigment Cell Differentiation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation
Tagcloud ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	actions affect colony competence consequences differently embryo embryonic embryos endometrium establish extend fetal granulocyte inner macrophage maintain maternal modulation numbers oviduct phenomenon postnatal pregnancy preimplantation respond responsible stimulating termed
Tagcloud (Difference) ?		agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	actions affect colony competence consequences differently embryo embryonic embryos endometrium establish extend fetal granulocyte inner macrophage maintain maternal modulation numbers oviduct phenomenon postnatal pregnancy preimplantation respond responsible stimulating termed
Tagcloud (Intersection) ?