CSF2 and IL3RA

Number of citations of the paper that reports this interaction (PMID 7957082)
13

Data Source:
HPRD (in vitro)

		CSF2	IL3RA
Gene Name		colony stimulating factor 2 (granulocyte-macrophage)	interleukin 3 receptor, alpha (low affinity)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity	Interleukin-3 Receptor Activity
	Biological Process	Embryonic Placenta Development Immune Response Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Interleukin-23 Production Epithelial Fluid Transport Macrophage Activation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Cytolysis Cellular Response To Lipopolysaccharide Positive Regulation Of Podosome Assembly Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs			Sargramostim
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 22446963)	Schizophrenia ( 17522711)
Protein-Protein Interactions		7 interactors: CSF2RA CSF2RB IL3RA KITLG MEOX2 PRG2 SDC2	15 interactors: CDC25A CDK1 CISH CSF2 CSF2RB FOXP1 GNA12 IL3 JAK1 JAK2 LNX1 NR0B2 PPP1CC SAE1 SGK2
Entrez ID		1437	3563
HPRD ID		00734	02392
Ensembl ID		ENSG00000164400	ENSG00000185291
Uniprot IDs		P04141	P26951
PDB IDs		1CSG 2GMF 3CXE
Enriched GO Terms of Interacting Partners?		Interleukin-3-mediated Signaling Pathway Cellular Response To Interleukin-3 Cytokine-mediated Signaling Pathway Response To Organic Substance Cellular Response To Cytokine Stimulus Interleukin-5-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Cytokine Defense Response To Nematode Cellular Response To Organic Substance Negative Regulation Of Mast Cell Apoptotic Process Regulation Of Mast Cell Apoptotic Process Somite Specification Positive Regulation Of Mast Cell Proliferation Response To Nematode Positive Regulation Of Melanocyte Differentiation Regulation Of Melanocyte Differentiation Positive Regulation Of Pigment Cell Differentiation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Developmental Pigmentation	Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of JAK-STAT Cascade Response To Organic Substance Cellular Response To Organic Substance Regulation Of Signaling Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Positive Regulation Of DNA Replication Regulation Of Signal Transduction Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Phosphorylation Cellular Protein Modification Process Response To Lipopolysaccharide Cellular Response To Stimulus Response To Molecule Of Bacterial Origin Response To Stimulus Response To Cytokine Regulation Of Protein Import Into Nucleus, Translocation Regulation Of DNA Replication Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of DNA Metabolic Process Positive Regulation Of Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Lipid Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Macrophage Activation Regulation Of Phosphorus Metabolic Process Response To Toxic Substance Regulation Of Protein Metabolic Process Response To Bacterium Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Growth Hormone Histone Phosphorylation Regulation Of Cardiac Muscle Cell Proliferation Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Intracellular Signal Transduction
Tagcloud ?		actions affect colony competence consequences differently embryo embryonic embryos endometrium establish extend fetal granulocyte inner macrophage maintain maternal modulation numbers oviduct phenomenon postnatal pregnancy preimplantation respond responsible stimulating termed	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		actions affect colony competence consequences differently embryo embryonic embryos endometrium establish extend fetal granulocyte inner macrophage maintain maternal modulation numbers oviduct phenomenon postnatal pregnancy preimplantation respond responsible stimulating termed	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?