MDK and SRPK2

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (enzymatic study)

		MDK	SRPK2
Gene Name		midkine (neurite growth-promoting factor 2)	SRSF protein kinase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Projection	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Growth Factor Activity Heparin Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding 14-3-3 Protein Binding
	Biological Process	Behavioral Fear Response Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Adrenal Gland Development Defecation Response To Drug Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division	Spliceosomal Complex Assembly Angiogenesis Protein Phosphorylation Positive Regulation Of Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Signaling by NOTCH2 Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)	Myopia (pathological) ( 23049088)
Protein-Protein Interactions		17 interactors: ALK JAK1 JAK2 LRP1 LRP2 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4	177 interactors: ABL1 ACIN1 ADPRH AES AHCYL1 ALKBH3 AMMECR1L APEX1 APOBEC3C APP ARGLU1 ARHGAP12 ARL6IP4 ARPC1B ATAT1 AURKA BAIAP2 BRD3 C16orf78 C17orf85 C18orf25 C1orf35 C4orf46 CACNG2 CAND1 CASK CBLN4 CBX5 CCDC28A CCDC97 CCM2 CDC42EP4 CDK7 CHD2 CHERP CHTOP CHUK CLDN19 CLK1 CLK2 CLK3 CSAG1 CTNNBL1 DAW1 DBF4B DDX21 DDX46 DDX6 DHX8 DNAJC8 DRAP1 DRG1 EGLN2 EIF1AY ENOX2 EPB41L1 EPB41L4A EPS8L3 ERCC3 ERN1 EVI5L FAM76B FAM90A1 FGF12 FOXN3 FXR2 GABARAP GABARAPL1 GPR114 GTF2E1 HBS1L HIRIP3 HMGN3 HNRNPC HOMER3 IFIT5 KCNN2 LCA5 LCE3D LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MAGEB1 MAPKAPK5 MARCH10 MCOLN3 MDK MPP3 MRPS6 NCK2 NELFE NGLY1 NOP16 NPM2 NSMCE4A NSRP1 NUP50 NXT2 OCEL1 PABPC4 PAK4 PDE7B PELI1 POLB PPIA PPIL1 PRKAA1 PRPF38A PRPF40A PSMA3 PTBP1 RBM15 RBM23 RBM39 RBM8A RIT1 RIT2 RNF4 RNPS1 RPL22 RPL39L RPL41 RSRC1 RSRC2 RSRP1 RTF1 RWDD2B SDR42E1 SEC23B SLAIN2 SNIP1 SNRNP27 SNRNP35 SNRNP70 SNURF SREK1 SRI SRRM1 SRSF1 SRSF12 SRSF3 SRSF5 SRSF7 SRSF8 SRSF9 STON1 SUPT16H TAF7L TCOF1 TDP2 TLE4 TNFRSF10C TNIP2 TPD52 TRA2A TRA2B TRIM41 TTN U2AF1 U2AF2 UBD UBE2E2 VAV2 VIMP VRK1 WDR5 YPEL2 YPEL3 YTHDC1 YWHAB ZMAT4 ZRANB2 ZRSR2 ZSCAN9
Entrez ID		4192	6733
HPRD ID		01200	04280
Ensembl ID		ENSG00000110492	ENSG00000135250
Uniprot IDs		P21741	P78362
PDB IDs		1MKC 1MKN	2X7G
Enriched GO Terms of Interacting Partners?		Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Extracellular Vesicular Exosome Assembly Response To Light Stimulus Protein Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Response To Radiation System Development Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Stimulus Developmental Process Regulation Of Cytokine-mediated Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Signaling Cell Communication Response To Abiotic Stimulus Multicellular Organismal Development Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transport Response To External Stimulus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Cellular Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Response To Interferon-gamma Glycoprotein Metabolic Process Glycosaminoglycan Metabolic Process Response To Toxic Substance Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Pathogenesis	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing DNA-templated Transcription, Termination Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing MRNA Export From Nucleus MRNA Transport RNA Export From Nucleus RNA 3'-end Processing RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Nuclear Export MRNA Splice Site Selection Negative Regulation Of RNA Splicing Spliceosomal Complex Assembly Nucleocytoplasmic Transport Nuclear Transport Cellular Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Ribonucleoprotein Complex Assembly Transcription, DNA-templated Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Intracellular Transport Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Establishment Of Localization In Cell Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle
Tagcloud ?		aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic	70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww
Tagcloud (Difference) ?		aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic	70k arginine asf clk cloning coexpressed contributing dipeptides nh2 pancreas phosphorylate preference preferred proline redistribution reversible rs sf2 similarities spliceosome splicing srpk1 stringent sty u1 uniquely ww
Tagcloud (Intersection) ?