MDK and TSPAN1

Number of citations of the paper that reports this interaction (PMID 18851943)
11

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		MDK	TSPAN1
Gene Name		midkine (neurite growth-promoting factor 2)	tetraspanin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Projection	Cytoplasm Lysosomal Membrane Plasma Membrane Membrane Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Growth Factor Activity Heparin Binding	Protein Binding Thiamine Uptake Transmembrane Transporter Activity
	Biological Process	Behavioral Fear Response Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Adrenal Gland Development Defecation Response To Drug Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division	Cell Proliferation Cell Migration Positive Regulation Of Endocytosis Protein Stabilization Thiamine Transmembrane Transport
Pathways		Signaling by NOTCH2 Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)
Protein-Protein Interactions		17 interactors: ALK JAK1 JAK2 LRP1 LRP2 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4	2 interactors: MDK NFKBIB
Entrez ID		4192	10103
HPRD ID		01200	18232
Ensembl ID		ENSG00000110492	ENSG00000117472
Uniprot IDs		P21741	O60635
PDB IDs		1MKC 1MKN
Enriched GO Terms of Interacting Partners?		Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Extracellular Vesicular Exosome Assembly Response To Light Stimulus Protein Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Response To Radiation System Development Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Stimulus Developmental Process Regulation Of Cytokine-mediated Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Signaling Cell Communication Response To Abiotic Stimulus Multicellular Organismal Development Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transport Response To External Stimulus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Cellular Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Response To Interferon-gamma Glycoprotein Metabolic Process Glycosaminoglycan Metabolic Process Response To Toxic Substance Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Pathogenesis	Defecation Short-term Memory Response To Lipid Dentate Gyrus Development Cerebellar Granular Layer Development Behavioral Fear Response Adrenal Gland Development Fear Response Defense Response Excretion Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cerebellar Cortex Development MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Hippocampus Development Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Multicellular Organismal Response To Stress
Tagcloud ?		aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic	adh7 archival assaying barrett benjamini cd151 cd9 cyclo dpyd duplicate eac egr1 endoscopy esophagus ets1 ffpe histopathology hochberg lined metaplasia mmp7 multiplexed oxygenase quantitate sparc tcirg1
Tagcloud (Difference) ?		aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic	adh7 archival assaying barrett benjamini cd151 cd9 cyclo dpyd duplicate eac egr1 endoscopy esophagus ets1 ffpe histopathology hochberg lined metaplasia mmp7 multiplexed oxygenase quantitate sparc tcirg1
Tagcloud (Intersection) ?