MAP2 and PLEC

Number of citations of the paper that reports this interaction (PMID 3027087)
32

Data Source:
HPRD (in vitro)

		MAP2	PLEC
Gene Name		microtubule-associated protein 2	plectin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Microtubule Microtubule Associated Complex Nuclear Periphery Neuronal Cell Body Dendritic Shaft	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Ankyrin Binding Poly(A) RNA Binding
	Biological Process	Microtubule Bundle Formation Axonogenesis Central Nervous System Neuron Development Neuron Projection Development Dendrite Morphogenesis Cellular Response To Organic Substance	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Extracellular Matrix Organization Hemidesmosome Assembly Cell Junction Assembly
Pathways			Cell junction organization Apoptotic cleavage of cellular proteins Type I hemidesmosome assembly Collagen formation Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins Assembly of collagen fibrils and other multimeric structures
Drugs		Estramustine Paclitaxel Docetaxel
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D JUNB MARK1 MARK3 MARK4 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 TUBA1A	17 interactors: ACTC1 ACTG1 CASP8 CDK1 COL17A1 EGFR GNB2L1 ITGA6 ITGB4 LMNB1 MAP2 MSN PLEKHA5 SMAD9 SPTA1 SPTAN1 VIM
Entrez ID		4133	5339
HPRD ID		01140	03180
Ensembl ID		ENSG00000078018	ENSG00000178209
Uniprot IDs		P11137 Q6NYC5	Q15149
PDB IDs			1MB8 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO
Enriched GO Terms of Interacting Partners?		Response To Peptide Hormone Response To Peptide Axon Development Response To Organonitrogen Compound Nervous System Development Cellular Component Assembly Neuron Development Response To Wounding Platelet Activation Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Neuromuscular Process Cell Projection Organization Movement Of Cell Or Subcellular Component Blood Coagulation Neuron Projection Morphogenesis Hemostasis Generation Of Neurons Response To Hormone Locomotion Neurogenesis Cell Morphogenesis Involved In Differentiation Axonogenesis Cell Morphogenesis Cell Development Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Cell Projection Morphogenesis Regulation Of Body Fluid Levels Response To Growth Factor Cell Part Morphogenesis Axon Guidance Chemotaxis Wound Healing Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway System Development Response To Organic Substance Transport Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To External Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cytoskeleton Organization Multicellular Organismal Development	Anatomical Structure Development Developmental Process Anatomical Structure Morphogenesis Movement Of Cell Or Subcellular Component Cell Differentiation Tissue Development Hemidesmosome Assembly Multicellular Organismal Development Cellular Component Disassembly Involved In Execution Phase Of Apoptosis System Development Execution Phase Of Apoptosis Cell Projection Organization Locomotion Cell Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Apoptotic Process Programmed Cell Death Neuron Projection Morphogenesis Cell Death Death Epithelium Development Cell-substrate Junction Assembly Axon Guidance Cell Morphogenesis Involved In Differentiation Nervous System Development Cell Adhesion Cell Junction Assembly Neuron Projection Development Nail Development Cell Projection Morphogenesis Cell Part Morphogenesis Single Organismal Cell-cell Adhesion Neuron Development Negative Regulation Of Cell Death Chemotaxis Generation Of Neurons Amelogenesis Cell Morphogenesis Organ Development Filopodium Assembly Neurogenesis Neuron Differentiation Cytoskeleton Organization Tube Development Astrocyte Development Digestive Tract Development Response To Ethanol Response To External Stimulus
Tagcloud ?		amorphous angiopathy autopsy congophilic cortices filaments frontal granular helical histologically immunolabeled immunolabeling immunolocalized map5 myelin neurofibrillary pallor plaques plastic pyramidal remarkable senile somata spongy sprouting stronger tangles temporal ultrastructurally	actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Difference) ?		amorphous angiopathy autopsy congophilic cortices filaments frontal granular helical histologically immunolabeled immunolabeling immunolocalized map5 myelin neurofibrillary pallor plaques plastic pyramidal remarkable senile somata spongy sprouting stronger tangles temporal ultrastructurally	actn1 b5 bcat1 carbamoyl ctnnd1 egfr1 eph filamin flna genego i2d interactors interologous metadherin mtdh nucleolin pathwaycommons plectin pycard pyd rpkm s100a2 serpinb5 signalings stratifin subpathway sum149 sum190 tfrc
Tagcloud (Intersection) ?