MAP2 and NEFL

Number of citations of the paper that reports this interaction (PMID 1902666)
7

Data Source:
BioGRID (pull down, pull down)

		MAP2	NEFL
Gene Name		microtubule-associated protein 2	neurofilament, light polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Microtubule Microtubule Associated Complex Nuclear Periphery Neuronal Cell Body Dendritic Shaft	Cytoplasm Cytosol Neurofilament Axon Growth Cone TSC1-TSC2 Complex
	Molecular Function	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Phospholipase Binding
	Biological Process	Microtubule Bundle Formation Axonogenesis Central Nervous System Neuron Development Neuron Projection Development Dendrite Morphogenesis Cellular Response To Organic Substance	Microtubule Cytoskeleton Organization Synaptic Transmission Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Response To Toxic Substance Peripheral Nervous System Axon Regeneration Axon Transport Of Mitochondrion Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone
Pathways			Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Unblocking of NMDA receptor, glutamate binding and activation Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		Estramustine Paclitaxel Docetaxel
Diseases
GWAS
Protein-Protein Interactions		24 interactors: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D JUNB MARK1 MARK3 MARK4 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 TUBA1A	29 interactors: BRD7 CCNC CDK5RAP2 CHD3 ENKD1 GRIN1 KDM1A KIFC3 KRT15 MAP2 MTMR2 MYO5A NDN NEFH NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SPTAN1 TERF1 TEX11 TSC1 TXLNB USP2 VIM YWHAG
Entrez ID		4133	4747
HPRD ID		01140	01206
Ensembl ID		ENSG00000078018
Uniprot IDs		P11137 Q6NYC5	P07196
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Peptide Hormone Response To Peptide Axon Development Response To Organonitrogen Compound Nervous System Development Cellular Component Assembly Neuron Development Response To Wounding Platelet Activation Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Differentiation Neuromuscular Process Cell Projection Organization Movement Of Cell Or Subcellular Component Blood Coagulation Neuron Projection Morphogenesis Hemostasis Generation Of Neurons Response To Hormone Locomotion Neurogenesis Cell Morphogenesis Involved In Differentiation Axonogenesis Cell Morphogenesis Cell Development Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Cell Projection Morphogenesis Regulation Of Body Fluid Levels Response To Growth Factor Cell Part Morphogenesis Axon Guidance Chemotaxis Wound Healing Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway System Development Response To Organic Substance Transport Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Response To External Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Peptide Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cytoskeleton Organization Multicellular Organismal Development	Nervous System Development Developmental Process Anatomical Structure Development Regulation Of Cellular Component Organization System Development Central Nervous System Development Organelle Organization Cell Differentiation Cell Projection Organization Regulation Of Cellular Protein Metabolic Process Generation Of Neurons Multicellular Organismal Development Negative Regulation Of Cellular Metabolic Process Neurogenesis Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Cell Cycle Cell Development Movement Of Cell Or Subcellular Component Microtubule-based Process Intermediate Filament Organization Axonogenesis Regulation Of Cellular Process Response To Stimulus G2/M Transition Of Mitotic Cell Cycle Axon Development Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Cycle Cellular Component Maintenance Chromatin Modification Negative Regulation Of Biosynthetic Process Neuron Development Regulation Of Transcription From RNA Polymerase II Promoter Neuron Projection Morphogenesis Myelination Axon Ensheathment Chromosome Organization Cell Cycle Process Regulation Of Gene Expression Regulation Of Microtubule-based Process Chromatin Organization Cell Morphogenesis Involved In Differentiation Intermediate Filament Cytoskeleton Organization Neuron Differentiation Intermediate Filament-based Process Protein Oligomerization Microtubule Bundle Formation Microtubule Cytoskeleton Organization Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Tagcloud ?		amorphous angiopathy autopsy congophilic cortices filaments frontal granular helical histologically immunolabeled immunolabeling immunolocalized map5 myelin neurofibrillary pallor plaques plastic pyramidal remarkable senile somata spongy sprouting stronger tangles temporal ultrastructurally	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Difference) ?		amorphous angiopathy autopsy congophilic cortices filaments frontal granular helical histologically immunolabeled immunolabeling immunolocalized map5 myelin neurofibrillary pallor plaques plastic pyramidal remarkable senile somata spongy sprouting stronger tangles temporal ultrastructurally	abcc3 abcc5 abcg2 aldh1 astrocytoma ckit dige enforcing exhibiting gbm gbms glioblastoma klf4 lna locked maldi multiforme nanog nestin neurofilament nucleic onco sensitized sox2 stemness temozolomide tmz tof u251
Tagcloud (Intersection) ?