MAGEA11 and PDE4B

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		MAGEA11	PDE4B
Gene Name		melanoma antigen family A, 11	phosphodiesterase 4B, cAMP-specific
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytosol Voltage-gated Calcium Channel Complex Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CAMP Binding Ion Channel Binding Metal Ion Binding
	Biological Process		Neutrophil Homeostasis CAMP Catabolic Process Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Cellular Response To Drug T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Relaxation Of Cardiac Muscle
Pathways			Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Opioid Signalling DARPP-32 events
Drugs			Adenosine monophosphate Caffeine Theophylline Dyphylline Pentoxifylline Enprofylline Ketotifen Iloprost Papaverine Theobromine Amrinone (R)-Mesopram Roflumilast Piclamilast 4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5\'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23007406) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634)
Protein-Protein Interactions		86 interactors: ACMSD ACTN1 AKR1C3 ALDH5A1 AR ARHGAP29 BCL2L11 BEX2 BIRC2 C18orf54 CCDC14 CCDC146 CCDC185 CDC20B CDKN2B CEP76 CLUAP1 COX7A2L CSNK2A1 DIEXF DNAJC10 DOCK10 ENOX2 EWSR1 FAM156A GNPDA1 HOXB5 IL11 IL6ST ILF3 JADE3 KIAA0408 LNX1 MAPK3 MCRS1 MED28 MGME1 MLF1 MTA1 MXD3 MYOZ1 NCOA2 NDEL1 NDUFAF1 NDUFB9 NIF3L1 NOL4 NOS3 NSUN4 OTUB2 PCBD2 PDE4B PHYH PIN4 PNKD PNKP POLR1D PRDX3 PRKRIP1 PSMF1 RADIL RBM23 SH2D4A SNX20 SNX7 STAR TCEA2 TCEANC TCF25 TEX37 THEM5 TMEM123 TPM3 TRIM27 TRIM51 TRMT1 TXN2 UBE2D4 USP20 VTA1 WDYHV1 WTAP ZBTB16 ZCCHC12 ZNF655 ZSWIM2	4 interactors: DISC1 MAGEA11 PRKACA RCBTB2
Entrez ID		4110	5142
HPRD ID		02281	02528
Ensembl ID		ENSG00000185247	ENSG00000184588
Uniprot IDs		G5E962 P43364	Q07343 Q59GM8
PDB IDs			1F0J 1JP1 1JP2 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 4KP6
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Cellular Process Positive Regulation Of Metabolic Process Gene Expression Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Metabolic Process Protein Polyubiquitination Negative Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Testosterone Biosynthetic Process Regulation Of Cell Death Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Rhythmic Process Cell Death Response To Lipopolysaccharide Death Negative Regulation Of Protein Metabolic Process Respiratory Electron Transport Chain Response To Molecule Of Bacterial Origin Regulation Of Cell Cycle Electron Transport Chain Oxidation-reduction Process Negative Regulation Of Catalytic Activity RNA Methylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Apoptotic Process Reproductive Structure Development Positive Regulation Of Gene Expression Reproductive System Development Negative Regulation Of Mitotic Cell Cycle Phase Transition Programmed Cell Death	Positive Regulation Of Dense Core Granule Biogenesis Histone H3-T6 Phosphorylation Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Protein Catabolic Process Cellular Metal Ion Homeostasis Positive Regulation Of Ran GTPase Activity Cellular Cation Homeostasis Cellular Ion Homeostasis Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Metal Ion Homeostasis Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Chemical Homeostasis Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus Regulation Of Signal Transduction Ion Homeostasis Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Mitochondrial Calcium Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Regulation Of Signaling Regulation Of Proteolysis Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Synapse Maturation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Homeostasis Triglyceride Catabolic Process Negative Regulation Of Adenylate Cyclase Activity TOR Signaling Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Metabolic Process
Tagcloud ?			acrdy2 acrodysostosis allosteric augmenting closing cognition consolidation cr3 dampening discover elucidation intellectual mechanistically mim modulators monophosphate nams neuroinflammation nonamyloid pde4a pde4d phosphodiesterase positron strict ucr2 ultra underexploited underscored
Tagcloud (Difference) ?			acrdy2 acrodysostosis allosteric augmenting closing cognition consolidation cr3 dampening discover elucidation intellectual mechanistically mim modulators monophosphate nams neuroinflammation nonamyloid pde4a pde4d phosphodiesterase positron strict ucr2 ultra underexploited underscored
Tagcloud (Intersection) ?