LRCH4 and CA8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LRCH4	CA8
Gene Name		leucine-rich repeats and calponin homology (CH) domain containing 4	carbonic anhydrase VIII
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	PML Body	Cytoplasm
	Molecular Function	Protein Binding	Carbonate Dehydratase Activity Zinc Ion Binding
	Biological Process	Nervous System Development	One-carbon Metabolic Process Phosphatidylinositol-mediated Signaling
Pathways
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661) Response to amphetamines ( 22952603)
Protein-Protein Interactions		9 interactors: CA8 KRT40 KRTAP10-7 KRTAP10-8 MDFI NOTCH2NL RBBP6 RTN4 SIN3A	9 interactors: CRX GGA2 HSD17B14 ITPR1 LNX1 LRCH4 MAGED1 SPDL1 TBX3
Entrez ID		4034	767
HPRD ID		10062	00266
Ensembl ID		ENSG00000077454
Uniprot IDs		O75427	P35219
PDB IDs			2W2J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Binding In Utero Embryonic Development Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding Negative Regulation Of Binding Response To Methylglyoxal Negative Regulation Of Histone H3-K27 Acetylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Chromatin Silencing Regulation Of Protein Localization To Nucleus Multicellular Organismal Development Regulation Of Binding Endoplasmic Reticulum Tubular Network Organization Embryo Development	Atrioventricular Bundle Cell Differentiation Follicle-stimulating Hormone Secretion Positive Regulation Of Photoreceptor Cell Differentiation
Tagcloud ?			a8344g anhydrase ataxia autophagic carbonic cerebellar cybrids distinctive encephalomyopathy exhibiting fibres gait harbouring inherited lc3 lifelong maternally merrf mtdna muscular myoclonus phospho ragged retardation staurosporine sts viii waddles wdl
Tagcloud (Difference) ?			a8344g anhydrase ataxia autophagic carbonic cerebellar cybrids distinctive encephalomyopathy exhibiting fibres gait harbouring inherited lc3 lifelong maternally merrf mtdna muscular myoclonus phospho ragged retardation staurosporine sts viii waddles wdl
Tagcloud (Intersection) ?