LRCH4 and RTN4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		LRCH4	RTN4
Gene Name		leucine-rich repeats and calponin homology (CH) domain containing 4	reticulon 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	PML Body	Intracellular Nuclear Envelope Endoplasmic Reticulum Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Poly(A) RNA Binding
	Biological Process	Nervous System Development	Angiogenesis Apoptotic Process Axonal Fasciculation Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Regulation Of Cell Migration Negative Regulation Of Axon Extension Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Cardiac Epithelial To Mesenchymal Transition Endoplasmic Reticulum Tubular Network Organization Regulation Of Branching Morphogenesis Of A Nerve
Pathways			Signalling by NGF Axonal growth inhibition (RHOA activation) p75NTR regulates axonogenesis p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS			Obesity (extreme) ( 19553259)
Protein-Protein Interactions		9 interactors: CA8 KRT40 KRTAP10-7 KRTAP10-8 MDFI NOTCH2NL RBBP6 RTN4 SIN3A	34 interactors: ARL6IP1 BAIAP2 BCL2 BCL2L1 CLN8 CNTNAP1 COL4A3BP CRMP1 FXR2 HLA-DPB1 LAMA4 LRCH4 LRPAP1 MBP NAPA NR4A1 PLEKHF2 POT1 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21
Entrez ID		4034	57142
HPRD ID		10062	07259
Ensembl ID		ENSG00000077454	ENSG00000115310
Uniprot IDs		O75427	Q9NQC3
PDB IDs			2G31 2JV5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Binding In Utero Embryonic Development Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding Negative Regulation Of Binding Response To Methylglyoxal Negative Regulation Of Histone H3-K27 Acetylation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Chromatin Silencing Regulation Of Protein Localization To Nucleus Multicellular Organismal Development Regulation Of Binding Endoplasmic Reticulum Tubular Network Organization Embryo Development	Transport Establishment Of Localization In Cell Membrane Organization Cell Part Morphogenesis Intracellular Transport Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Localization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Mitochondrial Membrane Organization Regulation Of Telomere Maintenance Via Telomerase Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Anoikis Regulation Of Telomerase Activity Neuromuscular Process Controlling Posture Regulation Of Anoikis Regulation Of Telomere Maintenance Immune Response-regulating Signaling Pathway RNA-dependent DNA Replication Regulation Of Autophagy Mitochondrion Morphogenesis Cell Morphogenesis Negative Regulation Of DNA Biosynthetic Process Vesicle-mediated Transport Immune Response-activating Cell Surface Receptor Signaling Pathway System Development Neuron Differentiation Nervous System Development Axonogenesis Release Of Cytochrome C From Mitochondria Regulation Of Cellular Component Organization Cell Projection Morphogenesis Telomere Maintenance Via Telomere Lengthening Antigen Receptor-mediated Signaling Pathway Generation Of Neurons Anatomical Structure Development Aging Axon Development Developmental Process Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Response To Alkaloid Regulation Of Mitochondrial Membrane Permeability Cell Morphogenesis Involved In Neuron Differentiation Intracellular Protein Transport Regulation Of Organelle Organization Regulation Of Membrane Permeability Neurogenesis Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Tagcloud ?			advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Difference) ?			advance caspase caspases cdd corrected crosstalk disrupted doi emerges extrinsic flice flip flipl impinging initiator juxtaposition localizes mams mechanistically mefs mitochondria morphology platforms publication restrict reticulon shaping spatially tethering
Tagcloud (Intersection) ?