PHOX2A and HAND2

Number of citations of the paper that reports this interaction (PMID 14506227)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PHOX2A	HAND2
Gene Name		paired-like homeobox 2a	heart and neural crest derivatives expressed 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin	Nuclear Chromatin Transcription Factor Complex Protein Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription AT DNA Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Noradrenergic Neuron Differentiation Transcription, DNA-templated Somatic Motor Neuron Differentiation Oculomotor Nerve Formation Trochlear Nerve Formation Locus Ceruleus Development Midbrain Development Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Dopaminergic Neuron Differentiation	Angiogenesis In Utero Embryonic Development Heart Looping Suckling Behavior Heart Morphogenesis Cardiac Right Ventricle Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Apoptotic Process Involved In Heart Morphogenesis Noradrenergic Neuron Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Heart Development Adult Heart Development Mesenchymal Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Tongue Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Thymus Development Peripheral Nervous System Neuron Development Palate Development Cartilage Morphogenesis Coronary Artery Morphogenesis Visceral Serous Pericardium Development Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ATF6B CREBBP HAND2 JUN PRKACA	14 interactors: CENPB COPS5 EP300 GATA4 HAND1 HEY2 HEYL NPM1 PHOX2A PPP2R5D PRKACA PRKCA TCF3 TCF4
Entrez ID		401	9464
HPRD ID		04129	03872
Ensembl ID		ENSG00000165462	ENSG00000164107
Uniprot IDs		O14813	P61296
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Negative Regulation Of DNA Binding Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Metabolic Process Outflow Tract Morphogenesis Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Embryonic Digit Morphogenesis Blood Vessel Development Positive Regulation Of Myeloid Cell Differentiation Vasculature Development Regulation Of Endothelial Cell Proliferation Regulation Of DNA Binding Regulation Of Smoothened Signaling Pathway Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Binding Embryonic Morphogenesis Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Cellular Response To Potassium Ion Starvation Regulation Of Myeloid Leukocyte Differentiation Regulation Of Osteoblast Differentiation Immune System Process Biosynthetic Process Innate Immune Response Cell Proliferation Involved In Outflow Tract Morphogenesis Leading Edge Cell Differentiation Visceral Serous Pericardium Development Histone H3-T6 Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Epithelial Cell Proliferation Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Response To Endoplasmic Reticulum Stress Embryonic Limb Morphogenesis Cardiovascular System Development Transcription From RNA Polymerase II Promoter	Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Muscle Structure Development Positive Regulation Of Transcription, DNA-templated Cardiovascular System Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cardiac Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Cardiac Ventricle Morphogenesis Tissue Development Anatomical Structure Morphogenesis Cardiac Right Ventricle Morphogenesis Atrioventricular Valve Morphogenesis Regulation Of Metabolic Process Cardiac Septum Development Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Atrioventricular Valve Development Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Binding Positive Regulation Of Dense Core Granule Biogenesis Cardiac Ventricle Development Regulation Of Cell Cycle Organ Development Striated Muscle Tissue Development Heart Valve Morphogenesis Heart Valve Development Muscle Tissue Development Transcription, DNA-templated Histone H3-T6 Phosphorylation Tissue Morphogenesis Epithelium Development System Development Energy Reserve Metabolic Process Cardiac Chamber Development RNA Biosynthetic Process Developmental Process Regulation Of Transcription, DNA-templated Embryo Development Regulation Of Nucleic Acid-templated Transcription Tube Development Regulation Of RNA Biosynthetic Process Regulation Of Heart Contraction
Tagcloud ?		abnormally abonormally adc adenosquamous alx1 bcl2 cancerous chga ema folx2 foxl2 hpp1 hypermethylation methyaltion methylated methylation msp myf6 nsclc oc2 offer pdgfra pitx2 rarb shed six6 smpd3 sox1 syn	absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin prevents progesterone proliferative simple stroma stromal suppress weak
Tagcloud (Difference) ?		abnormally abonormally adc adenosquamous alx1 bcl2 cancerous chga ema folx2 foxl2 hpp1 hypermethylation methyaltion methylated methylation msp myf6 nsclc oc2 offer pdgfra pitx2 rarb shed six6 smpd3 sox1 syn	absent adenocarcinoma adenocarcinomas archival atypia atypical benign crest diagnoses disordered embedded endometrial endometrioid endometrium exact helix hyperplasia hysterectomy lost moderate paraffin prevents progesterone proliferative simple stroma stromal suppress weak
Tagcloud (Intersection) ?