LIPC and APOB

Number of citations of the paper that reports this interaction (PMID 9685400)
4

Data Source:
HPRD (in vitro)

		LIPC	APOB
Gene Name		lipase, hepatic	apolipoprotein B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space High-density Lipoprotein Particle	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Actin Cytoskeleton Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Phospholipase Activity Triglyceride Lipase Activity Heparin Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding	Protein Binding Phospholipid Binding Heparin Binding Cholesterol Transporter Activity Lipase Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis	Retinoid Metabolic Process In Utero Embryonic Development Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Sperm Motility Response To Lipopolysaccharide Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Small Molecule Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Transmembrane Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus
Pathways			Lipoprotein metabolism LDL-mediated lipid transport Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Cell surface interactions at the vascular wall Platelet homeostasis Visual phototransduction Scavenging by Class H Receptors Platelet sensitization by LDL Scavenging by Class F Receptors Scavenging by Class A Receptors Scavenging by Class B Receptors Orphan transporters Retinoid metabolism and transport
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Alzheimer's disease (cognitive decline) ( 23535033) Amyotrophic lateral sclerosis ( 18084291) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Cognitive performance ( 20125193) HDL cholesterol ( 18193043 18193044 20864672 19060906 23505323 19060910 19060911 20686565) Hematological and biochemical traits ( 20139978) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23281178 22916037 19043545) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phospholipid levels (plasma) ( 22359512) Red blood cell traits ( 23222517) Triglycerides ( 18193043 20686565)	Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol ( 20864672 19060911 20686565) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 21059979 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Response to statin therapy ( 20339536) Triglycerides ( 18193044 20864672 19060906 19060911 17463246 20686565)
Protein-Protein Interactions		3 interactors: ADHFE1 APOB LRP1	22 interactors: AKT2 APOA1 ARFGAP1 BGN CALR CANX HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3
Entrez ID		3990	338
HPRD ID		01058	00133
Ensembl ID		ENSG00000166035	ENSG00000084674
Uniprot IDs		A6H8L5 E7EUJ1 P11150	P04114 Q59HB3 Q7Z7Q0
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipoprotein Transport Artery Morphogenesis Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Beta-amyloid Clearance Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Molecular Hydrogen Transport Steroid Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Light Stimulus Alcohol Metabolic Process Receptor-mediated Endocytosis Response To Selenium Ion Blood Vessel Morphogenesis Small Molecule Metabolic Process Very-low-density Lipoprotein Particle Assembly Response To Radiation Triglyceride Mobilization Blood Vessel Development Low-density Lipoprotein Particle Remodeling Regulation Of Phospholipase A2 Activity Vasculature Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Detection Of Stimulus 2-oxoglutarate Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Lipoprotein Catabolic Process Protein-lipid Complex Assembly Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Cholesterol Efflux Cellular Response To Prostaglandin Stimulus Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Biosynthetic Process Triglyceride Catabolic Process Regulation Of Cholesterol Efflux Low-density Lipoprotein Particle Clearance Aorta Morphogenesis Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling	Protein Folding Response To Unfolded Protein Receptor-mediated Endocytosis Protein Metabolic Process Chaperone-mediated Protein Folding Transport Cellular Protein Metabolic Process Vesicle-mediated Transport Protein Stabilization Plasma Lipoprotein Particle Clearance Endocytosis Regulation Of Protein Stability Protein Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Establishment Of Protein Localization Protein Localization Regulation Of Plasma Lipoprotein Particle Levels Response To Endoplasmic Reticulum Stress Establishment Of Localization In Cell Cholesterol Transport Sterol Transport Protein Refolding Cholesterol Homeostasis Sterol Homeostasis Endoplasmic Reticulum Unfolded Protein Response Homeostatic Process Cellular Response To Unfolded Protein Cholesterol Import Cellular Localization Regulation Of Protein Phosphorylation Posttranscriptional Regulation Of Gene Expression ER-nucleus Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Cellular Response To Topologically Incorrect Protein Response To Abiotic Stimulus Cellular Metabolic Process Lipid Homeostasis Cellular Response To Stress Response To Organic Substance Sequestering Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Secretion By Cell Lipid Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Chemical Homeostasis Lipid Localization Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Phosphorylation
Tagcloud ?		abcg2 accessed americans architecture blacks contrasting direction eagle ethnicities ethnicity exposing fourteen genotypic hispanic mexican nhanes phenome phewas pleiotropic pleiotropy protoporphyrin race replicated replicating rs1800588 rs2231142 snp surveys whites	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Difference) ?		abcg2 accessed americans architecture blacks contrasting direction eagle ethnicities ethnicity exposing fourteen genotypic hispanic mexican nhanes phenome phewas pleiotropic pleiotropy protoporphyrin race replicated replicating rs1800588 rs2231142 snp surveys whites	apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually
Tagcloud (Intersection) ?