APOB and PDIA4

Number of citations of the paper that reports this interaction (PMID 9694898)
19

Data Source:
HPRD (in vitro, in vivo)

		APOB	PDIA4
Gene Name		apolipoprotein B	protein disulfide isomerase family A, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Actin Cytoskeleton Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Endocytic Vesicle Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cell Surface Melanosome
	Molecular Function	Protein Binding Phospholipid Binding Heparin Binding Cholesterol Transporter Activity Lipase Binding Low-density Lipoprotein Particle Receptor Binding	Protein Disulfide Isomerase Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Retinoid Metabolic Process In Utero Embryonic Development Triglyceride Mobilization Receptor-mediated Endocytosis Spermatogenesis Nervous System Development Blood Coagulation Phototransduction, Visible Light Cholesterol Metabolic Process Fertilization Response To Virus Response To Carbohydrate Post-embryonic Development Response To Selenium Ion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Triglyceride Catabolic Process Cholesterol Transport Sperm Motility Response To Lipopolysaccharide Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Small Molecule Metabolic Process Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Leukocyte Migration Transmembrane Transport Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin Stimulus	Protein Folding Protein Secretion Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Chaperone-mediated Protein Folding
Pathways		Lipoprotein metabolism LDL-mediated lipid transport Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Cell surface interactions at the vascular wall Platelet homeostasis Visual phototransduction Scavenging by Class H Receptors Platelet sensitization by LDL Scavenging by Class F Receptors Scavenging by Class A Receptors Scavenging by Class B Receptors Orphan transporters Retinoid metabolism and transport
Drugs
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol ( 20864672 19060911 20686565) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18262040 23726366 21059979 18193043 18193044 20864672 19060906 19060910 19060911 20686565) Lipid metabolism phenotypes ( 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Response to statin therapy ( 20339536) Triglycerides ( 18193044 20864672 19060906 19060911 17463246 20686565)	Height ( 20881960)
Protein-Protein Interactions		22 interactors: AKT2 APOA1 ARFGAP1 BGN CALR CANX HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3	3 interactors: APOB BCL2L1 GADD45G
Entrez ID		338	9601
HPRD ID		00133	06501
Ensembl ID		ENSG00000084674	ENSG00000155660
Uniprot IDs		P04114 Q59HB3 Q7Z7Q0	P13667
PDB IDs			3IDV
Enriched GO Terms of Interacting Partners?		Protein Folding Response To Unfolded Protein Receptor-mediated Endocytosis Protein Metabolic Process Chaperone-mediated Protein Folding Transport Cellular Protein Metabolic Process Vesicle-mediated Transport Protein Stabilization Plasma Lipoprotein Particle Clearance Endocytosis Regulation Of Protein Stability Protein Transport Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Establishment Of Protein Localization Protein Localization Regulation Of Plasma Lipoprotein Particle Levels Response To Endoplasmic Reticulum Stress Establishment Of Localization In Cell Cholesterol Transport Sterol Transport Protein Refolding Cholesterol Homeostasis Sterol Homeostasis Endoplasmic Reticulum Unfolded Protein Response Homeostatic Process Cellular Response To Unfolded Protein Cholesterol Import Cellular Localization Regulation Of Protein Phosphorylation Posttranscriptional Regulation Of Gene Expression ER-nucleus Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Cellular Response To Topologically Incorrect Protein Response To Abiotic Stimulus Cellular Metabolic Process Lipid Homeostasis Cellular Response To Stress Response To Organic Substance Sequestering Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Secretion By Cell Lipid Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Chemical Homeostasis Lipid Localization Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Phosphorylation	Apoptotic Process In Bone Marrow Cellular Response To Acid Chemical Fertilization Response To Virus Suppression By Virus Of Host Apoptotic Process Response To Cycloheximide Cellular Process Regulating Host Cell Cycle In Response To Virus Response To Selenium Ion Activation Of MAPKKK Activity Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of P38MAPK Cascade Very-low-density Lipoprotein Particle Assembly Response To Radiation Triglyceride Mobilization Spermatogenesis Male Gamete Generation In Utero Embryonic Development Low-density Lipoprotein Particle Remodeling Cellular Response To Virus Modulation By Virus Of Host Process Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of P38MAPK Cascade Negative Regulation Of Anoikis Positive Regulation Of Cell Death Cellular Response To Gamma Radiation Hepatocyte Apoptotic Process Lipoprotein Catabolic Process Protein-lipid Complex Assembly Gamete Generation Endocytosis Positive Regulation Of Cholesterol Storage Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Anoikis Cellular Response To Prostaglandin Stimulus Lipoprotein Transport Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Cholesterol Biosynthetic Process Triglyceride Catabolic Process Response To Cytokine Response To Other Organism Mitochondrion Morphogenesis Modulation By Virus Of Host Morphology Or Physiology Low-density Lipoprotein Particle Clearance Response To Biotic Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Execution Phase Of Apoptosis Response To Stress Chordate Embryonic Development
Tagcloud ?		apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually	calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia3 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Difference) ?		apobec apolipoprotein appreciated auxiliary catalyzed chelating demonstration edit editing editosome ef1 ef2 exogenously hemagglutinin his6 linking mcardle mooring multiplicity p100 p240 p44 p66 presumptive quantitatively reconstituted tagged underscore virtually	calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia3 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Intersection) ?