LIMK2 and CDC42BPA

Number of citations of the paper that reports this interaction (PMID 11340065)
14

Data Source:
HPRD (in vitro)

		LIMK2	CDC42BPA
Gene Name		LIM domain kinase 2	CDC42 binding protein kinase alpha (DMPK-like)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cis-Golgi Network	Cytoplasm Cell-cell Junction Cell Leading Edge Actomyosin Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Heterodimerization Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Phosphorylation	Microtubule Cytoskeleton Organization Protein Phosphorylation Nuclear Migration Cell Migration Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways		EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Paclitaxel-induced neuropathy ( 23776197) Type 2 diabetes nephropathy ( 21150874)
Protein-Protein Interactions		9 interactors: CDC42BPA CFL1 GSN HIPK3 HIST1H1A LIMK1 MBP PARD3 ROCK1	6 interactors: CDC42 LIMK1 LIMK2 MYL2 MYL9 PPP1R12C
Entrez ID		3985	8476
HPRD ID		03585	04562
Ensembl ID		ENSG00000182541	ENSG00000143776
Uniprot IDs		E7EUC1 P53671	F5H5N0 Q5VT25
PDB IDs		1X6A
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Rho Protein Signal Transduction Apical Constriction Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Cell Projection Morphogenesis Cell Part Morphogenesis Neurogenesis Cell Morphogenesis Organelle Organization Regulation Of Cytoskeleton Organization Axonogenesis Cell Projection Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Positive Regulation Of Cytoskeleton Organization Nervous System Development Protein Phosphorylation Neuron Projection Morphogenesis Ras Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Actin-mediated Cell Contraction Generation Of Neurons Neuron Projection Development Cell Migration Epithelial Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Organelle Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Cell Development Regulation Of Stress Fiber Assembly Response To External Stimulus Regulation Of Actin Filament Depolymerization Phosphorylation Neuron Development Intracellular Signal Transduction Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Axon Guidance Execution Phase Of Apoptosis Positive Regulation Of Organelle Organization	Ephrin Receptor Signaling Pathway Axon Guidance Heart Contraction Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Actin Cytoskeleton Organization Cell Development Neuron Projection Morphogenesis Actin Filament-based Process Muscle Cell Fate Specification Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Muscle Contraction Cell Projection Morphogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Part Morphogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Actin Filament Branching Submandibular Salivary Gland Formation Neuron Development Cardiac Muscle Tissue Development Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Muscle Contraction Cell Morphogenesis Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Establishment Of Golgi Localization Phagocytosis Muscle System Process Fc Receptor Signaling Pathway Positive Regulation Of Metalloenzyme Activity Positive Regulation Of Cell Projection Organization Locomotion Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Fate Commitment Blood Circulation Positive Regulation Of Cellular Component Biogenesis Striated Muscle Tissue Development Neuron Fate Determination
Tagcloud ?		aberrant cdk4 cofilin cyclin d1 death downregulation drp1 dynamic effectors epilepticus fission interacting kip1 mediators necrotic neuronal p27 programmed rescue rho rock se subsequently turn unsuspected upregulated vulnerable
Tagcloud (Difference) ?		aberrant cdk4 cofilin cyclin d1 death downregulation drp1 dynamic effectors epilepticus fission interacting kip1 mediators necrotic neuronal p27 programmed rescue rho rock se subsequently turn unsuspected upregulated vulnerable
Tagcloud (Intersection) ?