LIMK2

Gene Name		LIM domain kinase 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cis-Golgi Network
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Spermatogenesis Phosphorylation
Pathways		EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Paclitaxel-induced neuropathy ( 23776197) Type 2 diabetes nephropathy ( 21150874)
Protein-protein Interactions		9 interactors: CDC42BPA CFL1 GSN HIPK3 HIST1H1A LIMK1 MBP PARD3 ROCK1
Entrez ID		3985
HPRD ID		03585
Ensembl ID		ENSG00000182541
Uniprot IDs		E7EUC1 P53671
PDB IDs		1X6A
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Regulation Of Actin Filament-based Process Cytoskeleton Organization Actin Cytoskeleton Organization Rho Protein Signal Transduction Apical Constriction Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Cell Projection Morphogenesis Cell Part Morphogenesis Neurogenesis Cell Morphogenesis Organelle Organization Regulation Of Cytoskeleton Organization Axonogenesis Cell Projection Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Positive Regulation Of Cytoskeleton Organization Nervous System Development Protein Phosphorylation Neuron Projection Morphogenesis Ras Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Actin-mediated Cell Contraction Generation Of Neurons Neuron Projection Development Cell Migration Epithelial Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Organelle Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Actin Filament-based Movement Cell Development Regulation Of Stress Fiber Assembly Response To External Stimulus Regulation Of Actin Filament Depolymerization Phosphorylation Neuron Development Intracellular Signal Transduction Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Axon Guidance Execution Phase Of Apoptosis Positive Regulation Of Organelle Organization
Tagcloud ?		aberrant cdk4 cofilin cyclin d1 death downregulation drp1 dynamic effectors epilepticus fission interacting kip1 mediators necrotic neuronal p27 programmed rescue rho rock se subsequently turn unsuspected upregulated vulnerable