STMN1 and HSPA5

Number of citations of the paper that reports this interaction (PMID 7724523)
23

Data Source:
HPRD (in vitro, two hybrid)

		STMN1	HSPA5
Gene Name		stathmin 1	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytosol Microtubule Membrane Neuron Projection Extracellular Vesicular Exosome	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Tubulin Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Microtubule Depolymerization Mitotic Spindle Organization Signal Transduction Axonogenesis Brain Development Response To Virus Negative Regulation Of Microtubule Polymerization Neuron Projection Development Intracellular Signal Transduction Positive Regulation Of Cellular Component Movement Regulation Of Cytoskeleton Organization	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport
Pathways			Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs			Antihemophilic Factor
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CAMK2G CDK1 CDKN1B CSNK2A1 GLP1R HSPA5 HSPA8 MAPK3 PRKACA RLIM SEPT2 SESTD1 SIVA1 STAT3 UBQLN4 UHMK1	53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB
Entrez ID		3925	3309
HPRD ID		01047	00682
Ensembl ID		ENSG00000117632	ENSG00000044574
Uniprot IDs		P16949	P11021
PDB IDs			3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Nervous System Development Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Peptide Hormone Response To Peptide Cell Cycle Regulation Of Cellular Response To Heat Cellular Response To Peptide Hormone Stimulus Regulation Of Metabolic Process Cellular Response To Peptide Cell Cycle Process Mitotic Cell Cycle Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Catabolic Process System Development Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Cell Development Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Intracellular Transport Response To Fibroblast Growth Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Neuron Projection Development Response To Organonitrogen Compound Signaling Cellular Response To Organonitrogen Compound Protein Autophosphorylation Regulation Of Cellular Protein Metabolic Process Cell Communication Cellular Response To Heat Regulation Of Cell Cycle Multicellular Organismal Development Response To Hormone Neuron Development Apoptotic Process Anatomical Structure Development Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Phase Transition Regulation Of Cell Death Generation Of Neurons	Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis
Tagcloud ?		actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately taqman tfrc top2a tubb3 tyms vegfr2	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Difference) ?		actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm gusb normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately taqman tfrc top2a tubb3 tyms vegfr2	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Intersection) ?