KRT14 and SUMO2

Number of citations of the paper that reports this interaction (PMID 21062750)
12

Data Source:
BioGRID (pull down)

		KRT14	SUMO2
Gene Name		keratin 14, type I	small ubiquitin-like modifier 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Extracellular Vesicular Exosome Cell Periphery	Nucleus Nucleoplasm PML Body
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Epithelial Cell Differentiation Hemidesmosome Assembly Cell Junction Assembly Hair Cycle Intermediate Filament Bundle Assembly	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Cell junction organization Type I hemidesmosome assembly	SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APC DST HSPA5 KRT5 PKP1 SUMO1 SUMO2 SUMO3 TCHP TRADD	91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5
Entrez ID		3861	6613
HPRD ID		01017	04332
Ensembl ID		ENSG00000186847	ENSG00000188612
Uniprot IDs		P02533	P61956
PDB IDs		3TNU	1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Hemidesmosome Assembly Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Cell Junction Assembly Post-translational Protein Modification Regulation Of Protein Metabolic Process Intermediate Filament Cytoskeleton Organization Peptidyl-lysine Modification Intermediate Filament-based Process Cell-substrate Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Execution Phase Of Apoptosis Regulation Of Protein Folding In Endoplasmic Reticulum Apoptotic Process Programmed Cell Death Cellular Component Assembly Cell Death Death Cerebellum Structural Organization Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Protein Localization To Organelle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Cell Cycle Arrest Cellular Response To Cytokine Stimulus PML Body Organization Negative Regulation Of Odontogenesis Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Complex Assembly Protein Localization To Nucleus Positive Regulation Of Cellular Metabolic Process Protein Localization To Nuclear Pore Intermediate Filament Bundle Assembly Response To Cytokine Protein Localization To Nuclear Envelope Metaphase/anaphase Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Regulation Of Protein Ubiquitination	Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress
Tagcloud ?		amu arising carcinogenic chimera densely distinguished earth elicits esr1 faster grew grow hosts ionizing irradiated k14 k18 keratin krt18 mev oncology radiation sham si sparsely stroma syngeneic tended trp53	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Difference) ?		amu arising carcinogenic chimera densely distinguished earth elicits esr1 faster grew grow hosts ionizing irradiated k14 k18 keratin krt18 mev oncology radiation sham si sparsely stroma syngeneic tended trp53	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Intersection) ?