KRAS and DNAJA3

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		KRAS	DNAJA3
Gene Name		Kirsten rat sarcoma viral oncogene homolog	DnaJ (Hsp40) homolog, subfamily A, member 3
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Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Actin Filament IkappaB Kinase Complex Extrinsic Component Of Plasma Membrane Cell Junction Neuromuscular Junction I-kappaB/NF-kappaB Complex Mitochondrial Nucleoid Intracellular Membrane-bounded Organelle Postsynaptic Membrane
	Molecular Function	Protein Binding GTP Binding GMP Binding GDP Binding LRR Domain Binding Protein Complex Binding	Small GTPase Regulator Activity Interferon-gamma Receptor Binding Protein Binding ATP Binding Transcription Factor Binding Protein Kinase Binding Hsp70 Protein Binding Receptor Tyrosine Kinase Binding Metal Ion Binding NF-kappaB Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Leukocyte Migration Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Epithelial Tube Branching Involved In Lung Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrial DNA Replication Protein Folding Negative Regulation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation-induced Cell Death Of T Cells Mitochondrion Organization Small GTPase Mediated Signal Transduction Neuromuscular Junction Development Cell Aging Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity T Cell Differentiation In Thymus Response To Interferon-gamma Protein Refolding Positive Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Catalytic Activity Protein Stabilization Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS
Protein-Protein Interactions		35 interactors: ADH6 APP ARAF BCL2 CALM1 CCT7 DDX47 DDX50 DNAJA3 EEF1A1 EGLN1 EPB42 FNTA FNTB HNRNPC IGSF21 LPAR1 MDFI PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PSMA3 RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 SHOC2 ZDHHC17	38 interactors: ALS2CR11 ATXN1 BRCA1 CARM1 COIL FAM131C FAM214B FOSL2 FRMD6 GCC1 GFI1B GRB2 HSPA1A HSPA8 HSPA9 IFNGR2 INPP5J JAK2 KDM1A KRAS MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 RAD51 RASA1 RELA RNF34 SMAD9 STK16 TCF19 USP7 VHL ZBTB22
Entrez ID		3845	9093
HPRD ID		01817	09758
Ensembl ID		ENSG00000133703	ENSG00000103423
Uniprot IDs		L7RSL8 P01116	B3KM81 E7ES32 Q53G26 Q59E88 Q96EY1
PDB IDs		1D8D 1D8E 1KZO 1KZP 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY	2CTT 2DN9
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Cell Communication Response To Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Platelet Activation Response To Wounding Positive Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Programmed Cell Death Positive Regulation Of Hydrolase Activity Regulation Of Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Death Death Protein Prenylation Wound Healing Blood Coagulation Small GTPase Mediated Signal Transduction Hemostasis Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process	Response To Abiotic Stimulus Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Response To Organic Substance Response To Organonitrogen Compound Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Regulation Of Cellular Process Cellular Response To Stress Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Viral Process Positive Regulation Of NF-kappaB Transcription Factor Activity Transcription, DNA-templated Regulation Of Signaling RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Histone H3-R2 Methylation Response To Organic Cyclic Compound Response To Radiation Regulation Of Histone H3-K4 Methylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Proliferation Cellular Response To Organonitrogen Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Stimulus Response To Temperature Stimulus
Tagcloud ?		bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus	acted adenocarcinoma allylamino causing cochaperone colony concluded conversely counteracting counterparts demethoxy differently egfr enhancing geldanamycin hsp70 hsp90 interacted inversely isoforms oncogenic orthotropic proteasomal restored subcutaneous tid1 ubiquitinylation xenograft
Tagcloud (Difference) ?		bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus	acted adenocarcinoma allylamino causing cochaperone colony concluded conversely counteracting counterparts demethoxy differently egfr enhancing geldanamycin hsp70 hsp90 interacted inversely isoforms oncogenic orthotropic proteasomal restored subcutaneous tid1 ubiquitinylation xenograft
Tagcloud (Intersection) ?