KRAS and IGSF21

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		KRAS	IGSF21
Gene Name		Kirsten rat sarcoma viral oncogene homolog	immunoglobin superfamily, member 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft	Extracellular Region
	Molecular Function	Protein Binding GTP Binding GMP Binding GDP Binding LRR Domain Binding Protein Complex Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Leukocyte Migration Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS			Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		35 interactors: ADH6 APP ARAF BCL2 CALM1 CCT7 DDX47 DDX50 DNAJA3 EEF1A1 EGLN1 EPB42 FNTA FNTB HNRNPC IGSF21 LPAR1 MDFI PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PSMA3 RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 SHOC2 ZDHHC17	32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		3845	84966
HPRD ID		01817	11309
Ensembl ID		ENSG00000133703	ENSG00000117154
Uniprot IDs		L7RSL8 P01116	Q96ID5
PDB IDs		1D8D 1D8E 1KZO 1KZP 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Cell Communication Response To Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Platelet Activation Response To Wounding Positive Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Programmed Cell Death Positive Regulation Of Hydrolase Activity Regulation Of Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Death Death Protein Prenylation Wound Healing Blood Coagulation Small GTPase Mediated Signal Transduction Hemostasis Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process	Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth
Tagcloud ?		bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus
Tagcloud (Difference) ?		bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus
Tagcloud (Intersection) ?