KIR3DL1 and HLA-B

Number of citations of the paper that reports this interaction (PMID 8046332)
59

Data Source:
HPRD (in vivo)

		KIR3DL1	HLA-B
Gene Name		killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	major histocompatibility complex, class I, B
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	HLA-B Specific Inhibitory MHC Class I Receptor Activity	Receptor Binding Peptide Antigen Binding TAP Binding Chaperone Binding
	Biological Process	Immune Response Signal Transduction Regulation Of Immune Response	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Dendritic Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Ankylosing spondylitis ( 21743469) Beta-2 microglubulin plasma levels ( 23417110) CD4:CD8 lymphocyte ratio ( 20045101) Cervical cancer ( 23482656) Drug-induced liver injury (flucloxacillin) ( 19483685) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Graves' disease ( 21841780) Height ( 19343178 23563607) HIV-1 control ( 20205591 21051598 20041166) Hypothyroidism ( 22493691) Multiple sclerosis ( 22190364 19525953) Nasopharyngeal carcinoma ( 20512145) Platelet counts ( 22139419) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		3 interactors: CDK3 HLA-B RPS6KB1	16 interactors: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3
Entrez ID		3811	3106
HPRD ID		09226	00828
Ensembl ID		ENSG00000167633	ENSG00000234745
Uniprot IDs		P43629 Q15702 Q5UCE2 Q8N6C9	E5FQ95 P01889 P30466 S6AU73
PDB IDs		3VH8	3VCL 4JQV
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle G0 To G1 Transition Positive Regulation Of Skeletal Muscle Tissue Growth Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Skeletal Muscle Atrophy Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To Leucine Striated Muscle Atrophy Muscle Atrophy Skeletal Muscle Adaptation Regulation Of Dendritic Cell Differentiation Regulation Of T Cell Anergy Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Translational Initiation Antigen Processing And Presentation Of Endogenous Antigen Mitotic Cell Cycle Process Response To Cytokine Response To Other Organism Detection Of Bacterium TOR Signaling Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To Biotic Stimulus Mitotic Cell Cycle Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Skeletal Muscle Tissue Development Skeletal Muscle Contraction Detection Of Biotic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Cell Cycle Response To Testosterone Negative Regulation Of Innate Immune Response Negative Regulation Of Insulin Receptor Signaling Pathway Protein Kinase B Signaling Regulation Of Smooth Muscle Cell Migration Response To Electrical Stimulus Musculoskeletal Movement Cell Cycle Process Long-term Memory Response To Glucagon Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Insulin Receptor Signaling Pathway Regulation Of T Cell Mediated Cytotoxicity Regulation Of Glucose Import	Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Immune System Process Innate Immune Response Leukocyte Differentiation Response To Molecule Of Bacterial Origin Cell Activation Cellular Response To Lipopolysaccharide Response To Other Organism Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Response To Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Response To Bacterium Immune Response-inhibiting Signal Transduction Leukocyte Activation Single Organismal Cell-cell Adhesion Regulation Of Dendritic Cell Differentiation Signal Transduction Cell Surface Receptor Signaling Pathway Response To Virus Hemopoiesis Signaling Response To Lipopolysaccharide Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Cellular Response To Organic Substance Positive Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Lymphocyte Activation Cellular Response To Lipid Defense Response To Virus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Immune System Process Response To Stimulus Immune Response-regulating Signaling Pathway Tissue Homeostasis Negative Regulation Of Cell Adhesion Viral Process Positive Regulation Of T Cell Activation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud ?		ab adaptor ap clathrin diminish diminished endocytosis endosomes engagement ig inhibitory internalization internalized itim killer kirs leaves maintaining mhc mu2 nk nonengaged prolonging readily recycling surface tyrosines undergoes
Tagcloud (Difference) ?		ab adaptor ap clathrin diminish diminished endocytosis endosomes engagement ig inhibitory internalization internalized itim killer kirs leaves maintaining mhc mu2 nk nonengaged prolonging readily recycling surface tyrosines undergoes
Tagcloud (Intersection) ?