HLA-B and KIR3DS1

Number of citations of the paper that reports this interaction (PMID 12134147)
260

Data Source:
HPRD (in vivo, in vitro)

		HLA-B	KIR3DS1
Gene Name		major histocompatibility complex, class I, B	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Peptide Antigen Binding TAP Binding Chaperone Binding	MHC Class I Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Dendritic Cell Differentiation	Immune Response Signal Transduction Natural Killer Cell Activation Innate Immune Response
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	DAP12 interactions Innate Immune System
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Beta-2 microglubulin plasma levels ( 23417110) CD4:CD8 lymphocyte ratio ( 20045101) Cervical cancer ( 23482656) Drug-induced liver injury (flucloxacillin) ( 19483685) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Graves' disease ( 21841780) Height ( 19343178 23563607) HIV-1 control ( 20205591 21051598 20041166) Hypothyroidism ( 22493691) Multiple sclerosis ( 22190364 19525953) Nasopharyngeal carcinoma ( 20512145) Platelet counts ( 22139419) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		16 interactors: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3	2 interactors: HLA-B TYROBP
Entrez ID		3106	3813
HPRD ID		00828	10034
Ensembl ID		ENSG00000234745
Uniprot IDs		E5FQ95 P01889 P30466 S6AU73	O43469 Q14943 Q4KN23 Q99565
PDB IDs		3VCL 4JQV
Enriched GO Terms of Interacting Partners?		Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Immune System Process Innate Immune Response Leukocyte Differentiation Response To Molecule Of Bacterial Origin Cell Activation Cellular Response To Lipopolysaccharide Response To Other Organism Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Response To Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Response To Bacterium Immune Response-inhibiting Signal Transduction Leukocyte Activation Single Organismal Cell-cell Adhesion Regulation Of Dendritic Cell Differentiation Signal Transduction Cell Surface Receptor Signaling Pathway Response To Virus Hemopoiesis Signaling Response To Lipopolysaccharide Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Cellular Response To Organic Substance Positive Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Lymphocyte Activation Cellular Response To Lipid Defense Response To Virus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Immune System Process Response To Stimulus Immune Response-regulating Signaling Pathway Tissue Homeostasis Negative Regulation Of Cell Adhesion Viral Process Positive Regulation Of T Cell Activation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion	Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Osteoclast Development Regulation Of Dendritic Cell Differentiation Neutrophil Activation Involved In Immune Response Regulation Of T Cell Anergy Macrophage Activation Involved In Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Innate Immune Response Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Immune Response Detection Of Bacterium Neutrophil Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Detection Of Biotic Stimulus Macrophage Activation Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Regulation Of Immune System Process Negative Regulation Of Innate Immune Response Defense Response Cellular Defense Response Regulation Of Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interleukin-12 Production Regulation Of Osteoclast Differentiation Response To External Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune System Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response Integrin-mediated Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Negative Regulation Of Immune Response Response To Interferon-gamma Leukocyte Activation Involved In Immune Response
Tagcloud ?			asian caucasians clustered han haplotype implied joining killer kir2dl2 kir2dl3 kir2dl5 kirs multidimensional neighbour outnumbered plot province southern ssp tree yunnan
Tagcloud (Difference) ?			asian caucasians clustered han haplotype implied joining killer kir2dl2 kir2dl3 kir2dl5 kirs multidimensional neighbour outnumbered plot province southern ssp tree yunnan
Tagcloud (Intersection) ?