KCNJ9 and DRD4

Number of citations of the paper that reports this interaction (PMID 12297500)
30

Data Source:
HPRD (in vitro, in vivo)

		KCNJ9	DRD4
Gene Name		potassium channel, inwardly rectifying subfamily J, member 9	dopamine receptor D4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Vesicle Membrane Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine
	Molecular Function	Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity PDZ Domain Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Dopamine Neurotransmitter Receptor Activity Protein Binding Drug Binding Potassium Channel Regulator Activity SH3 Domain Binding Dopamine Binding Identical Protein Binding
	Biological Process	Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Short-term Memory Circadian Rhythm Adult Locomotory Behavior Olfactory Learning Photoperiodism Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Regulation Of Neurotransmitter Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Response To Steroid Hormone Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Regulation Of Calcium-mediated Signaling Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Penile Erection Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Dopamine receptors
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Remoxipride Pramipexole Promazine Lisuride Apomorphine Risperidone Propiomazine Dopamine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Iloperidone Rotigotine Asenapine
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ADRB2 DRD2 DRD4 KCNJ3 KCNJ6	6 interactors: CLIC6 GABRA1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		3765	1815
HPRD ID		02959	00541
Ensembl ID			ENSG00000069696
Uniprot IDs		Q92806	P21917
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Transport Regulation Of Adenylate Cyclase Activity Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of CAMP Biosynthetic Process Regulation Of Ion Transmembrane Transport Regulation Of CAMP Metabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Dopaminergic Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Response To Histamine Behavioral Response To Ethanol G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission, Dopaminergic Arachidonic Acid Secretion Behavioral Response To Cocaine Regulation Of Neurotransmitter Uptake Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Potassium Ion Import Temperature Homeostasis Cell-cell Signaling Dopamine Metabolic Process Negative Regulation Of CAMP Biosynthetic Process Activation Of Protein Kinase Activity Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Response To Amphetamine Response To Abiotic Stimulus Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Long-chain Fatty Acid Transport Negative Regulation Of Calcium Ion Transport Catecholamine Metabolic Process Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Blood Pressure Response To Cocaine Response To Amine Negative Regulation Of Transmembrane Transport Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Acid Secretion	Transport Positive Regulation Of Cap-dependent Translational Initiation Positive Regulation Of Cap-independent Translational Initiation Positive Regulation Of Actin Filament Polymerization Chloride Transmembrane Transport Positive Regulation Of Protein Polymerization Chloride Transport Positive Regulation Of Translation In Response To Stress Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Cytoplasmic Translation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Peptidyl-serine Dephosphorylation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Cell-cell Signaling Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Complex Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Signal Transduction Inorganic Anion Transport Phagocytosis Cellular Response To Histamine Synaptic Transmission, GABAergic Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of T Cell Activation Positive Regulation Of Cell Activation Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Cellular Component Biogenesis Response To Histamine Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytoplasmic Translation Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Ion Transmembrane Transport Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Translational Initiation
Tagcloud ?			adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Difference) ?			adhd cleft clefting collect conceptual dat1 disabilities disruptive dopamine drd2 familial genotyped heritability hyperactivity impulse inattention inattentive neurobehavioral ofc orofacial overlap pilot polymorphisms proposing restlessness saliva stressors taq1a1 warranted
Tagcloud (Intersection) ?