ARF1 and ARHGAP21

Number of citations of the paper that reports this interaction (PMID 15793564)
36

Data Source:
HPRD (in vitro, two hybrid)

		ARF1	ARHGAP21
Gene Name		ADP-ribosylation factor 1	Rho GTPase activating protein 21
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Sarcomere Neuron Projection Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Golgi Membrane Golgi Apparatus Cytoskeleton Cell Junction Cytoplasmic Vesicle Membrane
	Molecular Function	GTPase Activity Receptor Signaling Protein Activity Protein Binding GTP Binding Poly(A) RNA Binding	Rho GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Receptor Internalization Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cellular Copper Ion Homeostasis Retrograde Vesicle-mediated Transport, Golgi To ER Post-Golgi Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Protein Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Arp2/3 Complex-mediated Actin Nucleation Small Molecule Metabolic Process COPI Coating Of Golgi Vesicle Regulation Of Defense Response To Virus By Virus Long Term Synaptic Depression Membrane Organization Dendritic Spine Organization	Golgi Organization Signal Transduction Positive Regulation Of Rho GTPase Activity Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule
Pathways		Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 EEF1G GGA1 GGA2 GGA3 GOSR2 INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA TMED10 TMED2 TMEM106A WBP11	6 interactors: ARF1 EEF1D PTK2B RHOA SP1 ZNF177
Entrez ID		375	57584
HPRD ID		00054	06445
Ensembl ID		ENSG00000143761	ENSG00000107863
Uniprot IDs		P84077	Q5T5U3
PDB IDs		1HUR 1RE0 1U81 3O47 4HMY	2DHJ 2J59 2YUY
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Intracellular Transport Establishment Of Localization In Cell Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Cellular Protein Localization Protein Localization COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Golgi Vesicle Transport Localization Within Membrane Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Transport Establishment Of Organelle Localization Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Organelle Localization Vesicle Targeting Membrane Organization Membrane Budding Organelle Organization Regulation Of ARF Protein Signal Transduction Cytoplasmic Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Anterograde Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Post-Golgi Vesicle-mediated Transport Anterograde Axon Cargo Transport ER To Golgi Vesicle-mediated Transport Regulation Of GTPase Activity Synaptic Vesicle Transport Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Establishment Of Golgi Localization Golgi To Vacuole Transport Regulation Of Ras Protein Signal Transduction Endosome To Melanosome Transport Cargo Loading Into Vesicle Pigment Granule Maturation Axon Cargo Transport Intra-Golgi Vesicle-mediated Transport Cellular Pigment Accumulation Cellular Pigmentation	Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Regulation Of Signaling Viral Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Sequestering Of Nodal From Receptor Via Nodal Binding Regulation Of CGMP-mediated Signaling Negative Regulation Of Nodal Signaling Pathway Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Intracellular Signal Transduction Skeletal Muscle Satellite Cell Migration Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Activation Of Janus Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Cell Junction Assembly Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Cell-cell Junction Organization Positive Regulation Of Neuron Projection Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Inositol Trisphosphate Biosynthetic Process Determination Of Left/right Asymmetry In Lateral Mesoderm Apolipoprotein A-I-mediated Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Nodal Signaling Pathway Cleavage Furrow Formation Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of Cell Projection Organization Cell Projection Organization Ossification Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Synaptic Transmission Positive Regulation Of Cellular Component Biogenesis Positive Regulation By Host Of Viral Transcription Activation Of Rac GTPase Activity Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Macrophage Chemotaxis Stress Fiber Assembly Embryonic Process Involved In Female Pregnancy Positive Regulation Of Neuron Differentiation COPI-coated Vesicle Budding Glial Cell Proliferation
Tagcloud ?		adp bulk close coated coatomer consumed contact copi dynamics endoplasmic exchange explored fission golgi governed gtpase interconnected maintain maintenance mitochondria mitochondrial powerhouse presumably produce proximity reticulum ribosylation thought vesicles
Tagcloud (Difference) ?		adp bulk close coated coatomer consumed contact copi dynamics endoplasmic exchange explored fission golgi governed gtpase interconnected maintain maintenance mitochondria mitochondrial powerhouse presumably produce proximity reticulum ribosylation thought vesicles
Tagcloud (Intersection) ?