ITGB3 and PECAM1

Number of citations of the paper that reports this interaction (PMID 10982404)
13

Data Source:
BioGRID (imaging technique)
HPRD (in vivo)

		ITGB3	PECAM1
Gene Name		integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	platelet/endothelial cell adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Melanosome Receptor Complex Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex	Extracellular Space Plasma Membrane Integral Component Of Membrane Cell Junction Platelet Alpha Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein Folding Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Growth Cell Migration Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Regulation Of Bone Resorption Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Angiogenesis Involved In Wound Healing Platelet Aggregation	Platelet Degranulation Phagocytosis Cell Adhesion Signal Transduction Blood Coagulation Cell Recognition Platelet Activation Extracellular Matrix Organization Leukocyte Migration Diapedesis Glomerular Endothelium Development
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation Non-integrin membrane-ECM interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation	Platelet homeostasis Platelet sensitization by LDL Response to elevated platelet cytosolic Ca2+ Platelet degranulation Integrin cell surface interactions Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall PECAM1 interactions
Drugs		Abciximab Eptifibatide Antithymocyte globulin Tirofiban
Diseases
GWAS
Protein-Protein Interactions		40 interactors: AKT1 ANGPTL3 CAPN1 CD36 CIB1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGG FLNA FLNB FN1 ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR NID1 NUMB P2RY2 PDGFRA PDGFRB PDPK1 PECAM1 PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN	22 interactors: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1
Entrez ID		3690	5175
HPRD ID		01428	01425
Ensembl ID		ENSG00000259207
Uniprot IDs		P05106	P16284
PDB IDs		1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4G1E 4G1M	2KY5
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Blood Coagulation Positive Regulation Of Cellular Component Movement Cell Adhesion Hemostasis Positive Regulation Of Locomotion Regulation Of Cell Migration Wound Healing Positive Regulation Of Phosphorylation Regulation Of Cell-substrate Adhesion Regulation Of Cell Motility Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Regulation Of Phosphorylation Cell-matrix Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Activation Blood Vessel Development Positive Regulation Of Protein Modification Process Signal Transduction Regulation Of Protein Phosphorylation Vasculature Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Metabolic Process Cell Communication Positive Regulation Of Kinase Activity Locomotion Anatomical Structure Morphogenesis Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Intracellular Signal Transduction Platelet Degranulation	Cell Migration Cell Motility Leukocyte Migration Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Blood Coagulation Hemostasis Wound Healing Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Body Fluid Levels T Cell Costimulation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Activation Cellular Response To Peptide Hormone Stimulus Innate Immune Response Positive Regulation Of Cell Activation Immune System Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Positive Regulation Of Immune Response Regulation Of Cell Activation Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Regulation Of T Cell Activation Regulation Of Cell Adhesion Response To Peptide Hormone Platelet Activation Response To Peptide Positive Regulation Of T Cell Activation Response To Stress Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Viral Process Defense Response Cellular Response To Hormone Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?		a4 acp5 apb b4 blt1 blt2 conclusionsin crac ctsk cytochemical erosion hydrolase introductionbone leukotriene leukotrienes lipoxygenase ltb4 manuscript methodswe mmp9 nfatc1 nucleated osteoclast osteoclasts pbmcs phospholipase resorbing resultsour u73122	alox15 ccl5 chd consisted cx37 cyp1a1 fcgr2a gpx1 harvested indian meta odd ppard rest retrieved rs1042522 rs1050450 rs1131012 rs12953 rs1764391 rs1801274 rs2016520 rs2107538 rs2228315 rs34210653 rs4646903 rs668 selplg variants
Tagcloud (Difference) ?		a4 acp5 apb b4 blt1 blt2 conclusionsin crac ctsk cytochemical erosion hydrolase introductionbone leukotriene leukotrienes lipoxygenase ltb4 manuscript methodswe mmp9 nfatc1 nucleated osteoclast osteoclasts pbmcs phospholipase resorbing resultsour u73122	alox15 ccl5 chd consisted cx37 cyp1a1 fcgr2a gpx1 harvested indian meta odd ppard rest retrieved rs1042522 rs1050450 rs1131012 rs12953 rs1764391 rs1801274 rs2016520 rs2107538 rs2228315 rs34210653 rs4646903 rs668 selplg variants
Tagcloud (Intersection) ?