ITGB3 and COL1A2

Number of citations of the paper that reports this interaction (PMID 1693626)
16

Data Source:
HPRD (in vivo, in vitro)

		ITGB3	COL1A2
Gene Name		integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	collagen, type I, alpha 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Melanosome Receptor Complex Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Protein Binding Protein Binding, Bridging Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein Folding Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Growth Cell Migration Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Regulation Of Bone Resorption Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Angiogenesis Involved In Wound Healing Platelet Aggregation	Skeletal System Development Blood Vessel Development Receptor-mediated Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Odontogenesis Skin Morphogenesis Leukocyte Migration Protein Heterotrimerization Cellular Response To Amino Acid Stimulus
Pathways		Signal transduction by L1 Axon guidance Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation Non-integrin membrane-ECM interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation	Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors
Drugs		Abciximab Eptifibatide Antithymocyte globulin Tirofiban
Diseases
GWAS			Aging ( 22773346) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Mean forced vital capacity from 2 exams ( 17903307)
Protein-Protein Interactions		40 interactors: AKT1 ANGPTL3 CAPN1 CD36 CIB1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGG FLNA FLNB FN1 ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR NID1 NUMB P2RY2 PDGFRA PDGFRB PDPK1 PECAM1 PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN	24 interactors: APP BGN CD36 CD44 CD93 COL5A3 DCN FN1 ITGA2 ITGA2B ITGB3 LIG4 LUM MMP9 MYOC P4HB PDGFA PDGFB SGTA SHBG SPARC TGFBI UBQLN1 VWF
Entrez ID		3690	1278
HPRD ID		01428	00363
Ensembl ID		ENSG00000259207	ENSG00000164692
Uniprot IDs		P05106	P08123
PDB IDs		1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Blood Coagulation Positive Regulation Of Cellular Component Movement Cell Adhesion Hemostasis Positive Regulation Of Locomotion Regulation Of Cell Migration Wound Healing Positive Regulation Of Phosphorylation Regulation Of Cell-substrate Adhesion Regulation Of Cell Motility Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Regulation Of Phosphorylation Cell-matrix Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Activation Blood Vessel Development Positive Regulation Of Protein Modification Process Signal Transduction Regulation Of Protein Phosphorylation Vasculature Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Metabolic Process Cell Communication Positive Regulation Of Kinase Activity Locomotion Anatomical Structure Morphogenesis Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Intracellular Signal Transduction Platelet Degranulation	Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Blood Coagulation Wound Healing Hemostasis Platelet Activation Response To Wounding Regulation Of Body Fluid Levels Cell Activation Exocytosis Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Secretion By Cell Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-substrate Adhesion Secretion System Development Cell-matrix Adhesion Anatomical Structure Development Positive Regulation Of Epithelial Cell Migration Extracellular Matrix Disassembly Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Chemotaxis Response To Stress Multicellular Organismal Development Developmental Process Regulation Of Cell Motility Organ Development Locomotion Regulation Of Locomotion Regulation Of Cellular Component Movement Glycosaminoglycan Catabolic Process Regulation Of Epithelial Cell Migration Response To External Stimulus Cell Development Response To Abiotic Stimulus Vesicle-mediated Transport Cell Projection Organization Anatomical Structure Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Axon Guidance Leukocyte Migration Tissue Development Positive Regulation Of Metanephric Mesenchymal Cell Migration
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