INSM1 and MPP3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		INSM1	MPP3
Gene Name		insulinoma-associated 1	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcriptional Repressor Complex	Integral Component Of Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Cyclin Binding Chromatin DNA Binding Histone Deacetylase Binding Metal Ion Binding	Guanylate Kinase Activity PDZ Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Phosphorylation Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Type B Pancreatic Cell Development Noradrenergic Neuron Development Transcription, DNA-templated Cell Cycle Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Endocrine Pancreas Development Norepinephrine Biosynthetic Process Regulation Of Protein Complex Assembly Positive Regulation Of Cell Differentiation Transdifferentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Neural Precursor Cell Proliferation	Signal Transduction Nucleotide Phosphorylation
Pathways		Regulation of beta-cell development Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CCND1 MPP3 SORBS1 TUBB3	33 interactors: APP ARL2BP CADM1 CCDC137 CRABP1 ERBB2IP EZR FAM171B GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZPR1
Entrez ID		3642	4356
HPRD ID		02480	03069
Ensembl ID		ENSG00000173404	ENSG00000161647
Uniprot IDs		Q01101	Q13368
PDB IDs		2LV2 3ZMS
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Binding Cell Growth Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Binding Regulation Of Protein Homodimerization Activity Growth Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle MRNA Metabolic Process Positive Regulation Of Binding Cellular Response To Epidermal Growth Factor Stimulus Multicellular Organismal Development Asymmetric Protein Localization System Development Establishment Or Maintenance Of Apical/basal Cell Polarity RNA Processing DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Signal Transduction Response To Epidermal Growth Factor DNA Strand Elongation Organelle Organization Exocytosis RNA Splicing Signaling Cellular Protein Localization G1/S Transition Of Mitotic Cell Cycle Cell Communication Nervous System Development Receptor Internalization Cellular Component Assembly Positive Regulation Of Interleukin-15 Production Nuclear Speck Organization Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Neurotrophin Production Dermatan Sulfate Catabolic Process Positive Regulation Of Nonmotile Primary Cilium Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Pre-mRNA Catabolic Process DNA Endoreduplication Signal Transduction Positive Regulation Of Innate Immune Response Protein Localization Regulation Of Phosphorus Metabolic Process
Tagcloud ?		acetyl akt ar42j beta2 conclude elevation enhance enhancer enhances enhancing extra h4 inr interrupts islet ly294002 modification neurod nkx6 pancreas pi3k possesses proline rack1 regulators repressor rich terminus trans	17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue
Tagcloud (Difference) ?		acetyl akt ar42j beta2 conclude elevation enhance enhancer enhances enhancing extra h4 inr interrupts islet ly294002 modification neurod nkx6 pancreas pi3k possesses proline rack1 regulators repressor rich terminus trans	17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue
Tagcloud (Intersection) ?