FASLG and PTPN13

Number of citations of the paper that reports this interaction (PMID 16498403)
47

Data Source:
HPRD (in vitro, in vivo)

		FASLG	PTPN13
Gene Name		Fas ligand (TNF superfamily, member 6)	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	21 interactors: APC ARHGAP29 BRD7 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR NFKBIA NGFR NGFRAP1 PDLIM4 PKN2 PLEKHA1 PRKACA RAPGEF6 TRIP6 YWHAZ
Entrez ID		356	5783
HPRD ID		00610	02602
Ensembl ID		ENSG00000117560	ENSG00000163629
Uniprot IDs		P48023 Q53ZZ1	Q12923
PDB IDs		1BZI	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Signal Transduction Signaling Cell Communication Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Proliferation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Necroptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Cell Adhesion T Cell Differentiation In Thymus Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Death Cell-cell Junction Organization Motor Neuron Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of Myeloid Leukocyte Differentiation Necroptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Intersection) ?