FASLG and FNBP1

Number of citations of the paper that reports this interaction (PMID 12023017)
6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		FASLG	FNBP1
Gene Name		Fas ligand (TNF superfamily, member 6)	formin binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Lysosome Cytoskeleton Plasma Membrane Coated Pit Cell Cortex Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Endocytosis
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	13 interactors: AKAP9 ARHGAP17 CBL CDC42 DNM1 DNM2 FASLG ITSN1 PDE6G RND2 SNX2 TNKS WASL
Entrez ID		356	23048
HPRD ID		00610	10446
Ensembl ID		ENSG00000117560	ENSG00000187239
Uniprot IDs		P48023 Q53ZZ1	B7ZL12 B7ZL13 B7ZL14 Q96RU3
PDB IDs		1BZI	2EFL
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Signal Transduction Ephrin Receptor Signaling Pathway Negative Regulation Of Membrane Tubulation Signaling Cell Communication Endocytosis Cellular Response To Stimulus Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Neuron Projection Morphogenesis Cell Projection Organization Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Establishment Of Organelle Localization Response To Stimulus Positive Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Organelle Localization Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Cell-cell Signaling Generation Of Neurons Regulation Of Catalytic Activity Neuron Development Regulation Of Cell Projection Organization Nitric Oxide Metabolic Process Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Neurogenesis Reactive Nitrogen Species Metabolic Process Endosome Organization Axonogenesis Positive Regulation Of Cellular Metabolic Process Establishment Of Vesicle Localization Regulation Of Intracellular Signal Transduction Vesicle Localization Positive Regulation Of Receptor-mediated Endocytosis Axon Development Regulation Of Nitric-oxide Synthase Activity Anatomical Structure Development Response To External Stimulus
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	11p 12p 17q11 6q16 9p21 9q34 af10 c9orf78 calm concurring cryptic del grik2 hoxa imbalances immunophenotyping interphase inup214 leukemias lymphoblastic nup214 q11 q12 q34 q35 taf tcrb tlx3 usp20
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	11p 12p 17q11 6q16 9p21 9q34 af10 c9orf78 calm concurring cryptic del grik2 hoxa imbalances immunophenotyping interphase inup214 leukemias lymphoblastic nup214 q11 q12 q34 q35 taf tcrb tlx3 usp20
Tagcloud (Intersection) ?