POLN and POLDIP2

Number of citations of the paper that reports this interaction (PMID 20554254)
7

Data Source:
BioGRID (two hybrid)

		POLN	POLDIP2
Gene Name		polymerase (DNA directed) nu	polymerase (DNA-directed), delta interacting protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Intracellular Membrane-bounded Organelle	Nucleus Mitochondrion Mitochondrial Nucleoid
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Cyclin Binding	DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA-dependent DNA Replication Translesion Synthesis Interstrand Cross-link Repair	Mitochondrion Morphogenesis
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 22159054)
Protein-Protein Interactions		2 interactors: ATR POLDIP2	14 interactors: ALAS1 APP ASCC2 CPE HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN REV1 SELENBP1 TAB1
Entrez ID		353497	26073
HPRD ID		17876	17874
Ensembl ID		ENSG00000130997	ENSG00000004142
Uniprot IDs		Q7Z5Q5	Q9Y2S7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Cellular Response To Gamma Radiation Mitochondrion Morphogenesis Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Substrate Adhesion-dependent Cell Spreading Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Replication Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Heat Positive Regulation Of Response To DNA Damage Stimulus Actin Cytoskeleton Reorganization Cell Aging Double-strand Break Repair Via Homologous Recombination Recombinational Repair	Translesion Synthesis Postreplication Repair DNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process DNA Repair DNA Replication Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-dependent DNA Replication Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Nucleobase-containing Compound Metabolic Process DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA Metabolic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Macromolecule Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transcription-coupled Nucleotide-excision Repair DNA Recombination Cellular Metabolic Process Cellular Response To Stimulus Mismatch Repair Base-excision Repair Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Deoxyribonuclease Activity Hsp90 Deacetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Telomere Maintenance Regulation Of Catalytic Activity Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Polyubiquitinated Misfolded Protein Transport Nucleotide-excision Repair Regulation Of Protein Processing Positive Regulation Of Cellular Metabolic Process
Tagcloud ?			atherosclerosis cdk1 curves cyclina2 delta die doubling e2f elongation embryos heterozygous homozygous lc3b mefs nox4 originally p21cip1 partner passage pcna proliferating restenosis s20 sirt1 sv40 transfection unaffected underline understudied
Tagcloud (Difference) ?			atherosclerosis cdk1 curves cyclina2 delta die doubling e2f elongation embryos heterozygous homozygous lc3b mefs nox4 originally p21cip1 partner passage pcna proliferating restenosis s20 sirt1 sv40 transfection unaffected underline understudied
Tagcloud (Intersection) ?