IGFBP4 and HK3

Number of citations of the paper that reports this interaction (PMID 11068878)
4

Data Source:
HPRD (two hybrid, in vitro)

		IGFBP4	HK3
Gene Name		insulin-like growth factor binding protein 4	hexokinase 3 (white cell)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Mitochondrion Cytosol Protein Complex
	Molecular Function	Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Glucokinase Activity Hexokinase Activity ATP Binding Fructokinase Activity Mannokinase Activity Enzyme Binding Hormone Binding
	Biological Process	Skeletal System Development Regulation Of Cell Growth DNA Metabolic Process Inflammatory Response Signal Transduction Cell Proliferation Regulation Of Glucose Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycolytic Process Hexose Transport Pathogenesis Glucose Transport Hexose Metabolic Process Small Molecule Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport
Drugs
Diseases
GWAS		Height ( 23563607)
Protein-Protein Interactions		8 interactors: CTSD HK3 IGF1 IGF2 KDM1A PAPPA SUV39H1 TF	9 interactors: ATF4 GRN HPGDS IGFBP4 LEP MITF PPP2CB PTGDS ZBTB17
Entrez ID		3487	3101
HPRD ID		00900	00806
Ensembl ID		ENSG00000141753	ENSG00000160883
Uniprot IDs		P22692	P52790
PDB IDs		1WQJ 2DSP 2DSQ 2DSR	3HM8
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Exocrine Pancreas Development Positive Regulation Of Hormone Biosynthetic Process Blood Coagulation Hemostasis Positive Regulation Of Glycogen Biosynthetic Process Regulation Of Body Fluid Levels Positive Regulation Of Activated T Cell Proliferation Wound Healing Platelet Activation Regulation Of Hormone Biosynthetic Process Response To Wounding Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Metabolic Process Regulation Of Hormone Metabolic Process Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Metabolic Process Positive Regulation Of Mitotic Nuclear Division Muscle Cell Differentiation Positive Regulation Of Neural Precursor Cell Proliferation Exocytosis Exocrine System Development Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Protein Kinase B Signaling Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of T Cell Proliferation Regulation Of DNA Binding Pancreas Development Muscle Structure Development Secretion By Cell Regulation Of Glucose Metabolic Process Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Nuclear Division Regulation Of Protein Kinase B Signaling Positive Regulation Of Cell Division Secretion Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Regulation Of T Cell Proliferation Digestive System Development Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Activation Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Negative Regulation Of Oocyte Development Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Muscle Cell Development	Cyclooxygenase Pathway Response To Endoplasmic Reticulum Stress Prostaglandin Biosynthetic Process Signal Transduction Prostaglandin Metabolic Process Response To Stimulus Signaling Cell Communication Icosanoid Biosynthetic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Phosphorylation Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Nuclease Activity Fatty Acid Metabolic Process Cellular Response To Stimulus Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Cellular Response To L-ascorbic Acid Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Endoplasmic Reticulum Unfolded Protein Response Organic Acid Metabolic Process Negative Regulation Of Ion Transport Icosanoid Metabolic Process Cellular Response To Unfolded Protein Regulation Of Glucose Metabolic Process Unsaturated Fatty Acid Metabolic Process ER-nucleus Signaling Pathway Positive Regulation Of Hepatic Stellate Cell Activation Cellular Response To Topologically Incorrect Protein Regulation Of Phosphorylation Long-chain Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Response To Unfolded Protein Negative Regulation Of Vasoconstriction Glycerol Biosynthetic Process Negative Regulation Of Glucagon Secretion Regulation Of Lipoprotein Lipid Oxidation Fatty Acid Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Glucose Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorus Metabolic Process Carbohydrate Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of STAT Protein Import Into Nucleus Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Circadian Rhythm
Tagcloud ?		absence added alteration autocrine concluded depend describes differ driven hormones igfir inducible mcf membranes mi7 mitogenic oestrogen onto overcome polycarbonate result secreted serum steroid transfected untransfected vector would	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?		absence added alteration autocrine concluded depend describes differ driven hormones igfir inducible mcf membranes mi7 mitogenic oestrogen onto overcome polycarbonate result secreted serum steroid transfected untransfected vector would	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Intersection) ?