HK3 and HPGDS

Number of citations of the paper that reports this interaction (PMID 11068878)
4

Data Source:
HPRD (in vitro, two hybrid)

		HK3	HPGDS
Gene Name		hexokinase 3 (white cell)	hematopoietic prostaglandin D synthase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Protein Complex	Cytoplasm Cytosol
	Molecular Function	Glucokinase Activity Hexokinase Activity ATP Binding Fructokinase Activity Mannokinase Activity Enzyme Binding Hormone Binding	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Homodimerization Activity
	Biological Process	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycolytic Process Hexose Transport Pathogenesis Glucose Transport Hexose Metabolic Process Small Molecule Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport	Prostaglandin Metabolic Process Xenobiotic Metabolic Process Signal Transduction Locomotory Behavior Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process
Pathways		Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Arachidonic acid metabolism Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			Glutathione 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glycerol 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		9 interactors: ATF4 GRN HPGDS IGFBP4 LEP MITF PPP2CB PTGDS ZBTB17	4 interactors: ABHD17A ARRDC3 HK3 MFI2
Entrez ID		3101	27306
HPRD ID		00806	04001
Ensembl ID		ENSG00000160883	ENSG00000163106
Uniprot IDs		P52790	O60760
PDB IDs		3HM8	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0
Enriched GO Terms of Interacting Partners?		Cyclooxygenase Pathway Response To Endoplasmic Reticulum Stress Prostaglandin Biosynthetic Process Signal Transduction Prostaglandin Metabolic Process Response To Stimulus Signaling Cell Communication Icosanoid Biosynthetic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Phosphorylation Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Nuclease Activity Fatty Acid Metabolic Process Cellular Response To Stimulus Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Cellular Response To L-ascorbic Acid Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Endoplasmic Reticulum Unfolded Protein Response Organic Acid Metabolic Process Negative Regulation Of Ion Transport Icosanoid Metabolic Process Cellular Response To Unfolded Protein Regulation Of Glucose Metabolic Process Unsaturated Fatty Acid Metabolic Process ER-nucleus Signaling Pathway Positive Regulation Of Hepatic Stellate Cell Activation Cellular Response To Topologically Incorrect Protein Regulation Of Phosphorylation Long-chain Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Response To Unfolded Protein Negative Regulation Of Vasoconstriction Glycerol Biosynthetic Process Negative Regulation Of Glucagon Secretion Regulation Of Lipoprotein Lipid Oxidation Fatty Acid Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Glucose Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorus Metabolic Process Carbohydrate Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of STAT Protein Import Into Nucleus Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Circadian Rhythm	Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Heat Generation Positive Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Extracellular Matrix Disassembly Homeostatic Process Positive Regulation Of Plasminogen Activation Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Fat Pad Development Negative Regulation Of Multicellular Organismal Metabolic Process Iron Ion Import Cellular Chemical Homeostasis Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Temperature Homeostasis Cellular Homeostasis Regulation Of Extracellular Matrix Disassembly Regulation Of Substrate Adhesion-dependent Cell Spreading Glucose 6-phosphate Metabolic Process Adipose Tissue Development Regulation Of Extracellular Matrix Organization Chemical Homeostasis Negative Regulation Of Cell-substrate Adhesion Carbohydrate Phosphorylation Glucose Transport Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Glucose Homeostasis Positive Regulation Of Ligase Activity Hexose Transport Iron Ion Transport
Tagcloud ?		5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?		5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf	11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?