IGFALS and IGFBP3

Number of citations of the paper that reports this interaction (PMID 9497324)
15

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo, in vitro)

		IGFALS	IGFBP3
Gene Name		insulin-like growth factor binding protein, acid labile subunit	insulin-like growth factor binding protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Insulin-like Growth Factor Binding Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Insulin-like Growth Factor Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	Cell Adhesion Signal Transduction Cellular Protein Metabolic Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs			Mecasermin
Diseases
GWAS		Insulin-like growth factors ( 21216879)	Insulin-like growth factors ( 21216879) Major depressive disorder ( 23377640) Ventricular conduction ( 21076409)
Protein-Protein Interactions		4 interactors: IGF1 IGFBP3 IGFBP5 PDCD6	28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF
Entrez ID		3483	3486
HPRD ID		03290	00899
Ensembl ID		ENSG00000099769	ENSG00000146674
Uniprot IDs		P35858 Q8TAY0	B3KPF0 B3KWK7 P17936
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Proliferation Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Protein Kinase B Signaling Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Ossification Regulation Of Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Regulation Of Growth Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Cell Proliferation Response To Heat Tissue Remodeling Positive Regulation Of Intracellular Signal Transduction Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Osteoblast Differentiation Positive Regulation Of Epithelial Cell Proliferation Apoptotic Process Gland Morphogenesis Regulation Of Signaling Programmed Cell Death Mammary Gland Development Cell Death Death Response To Temperature Stimulus Negative Regulation Of Cell Migration Regulation Of Ossification Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Skeletal Muscle Tissue Growth Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Striated Muscle Cell Differentiation Positive Regulation Of Signal Transduction Negative Regulation Of Oocyte Development	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Hemostasis Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Fibrinolysis Platelet Activation Leukocyte Migration Positive Regulation Of Fibrinolysis Platelet Degranulation Response To Stimulus Proteolysis Fibrinolysis Exocrine Pancreas Development Regulation Of Blood Coagulation Response To Stress Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Anatomical Structure Morphogenesis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Wound Healing Prostate Gland Development Organ Morphogenesis Acute Inflammatory Response Vasculature Development Immune System Process Movement Of Cell Or Subcellular Component Factor XII Activation Cardiovascular System Development Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Processing Locomotion Cell Activation Regulation Of Mitotic Nuclear Division Prostate Gland Epithelium Morphogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis
Tagcloud ?		112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation igf1 imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts
Tagcloud (Difference) ?		112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts
Tagcloud (Intersection) ?		igf1