IGFALS and PDCD6

Number of citations of the paper that reports this interaction (PMID 11591653)
37

Data Source:
HPRD (in vivo)

		IGFALS	PDCD6
Gene Name		insulin-like growth factor binding protein, acid labile subunit	programmed cell death 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site
	Molecular Function	Insulin-like Growth Factor Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Protein Homodimerization Activity Protein Anchor Protein Dimerization Activity Calcium-dependent Protein Binding Binding, Bridging
	Biological Process	Cell Adhesion Signal Transduction Cellular Protein Metabolic Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Proteolysis Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Insulin-like growth factors ( 21216879)
Protein-Protein Interactions		4 interactors: IGF1 IGFBP3 IGFBP5 PDCD6	18 interactors: ANXA11 ANXA7 CDKN2A CPNE1 CPNE2 CPNE4 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 SH3KBP1 TIMM22 VPS37C YWHAQ
Entrez ID		3483	10016
HPRD ID		03290	03035
Ensembl ID		ENSG00000099769	ENSG00000249915
Uniprot IDs		P35858 Q8TAY0	O75340 Q53FC3
PDB IDs			2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Proliferation Regulation Of Glucose Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Protein Kinase B Signaling Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Carbohydrate Metabolic Process Type B Pancreatic Cell Proliferation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Ossification Regulation Of Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Regulation Of Growth Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Cell Proliferation Response To Heat Tissue Remodeling Positive Regulation Of Intracellular Signal Transduction Regulation Of Osteoblast Differentiation Regulation Of Signal Transduction Osteoblast Differentiation Positive Regulation Of Epithelial Cell Proliferation Apoptotic Process Gland Morphogenesis Regulation Of Signaling Programmed Cell Death Mammary Gland Development Cell Death Death Response To Temperature Stimulus Negative Regulation Of Cell Migration Regulation Of Ossification Prostate Gland Stromal Morphogenesis Glycolate Metabolic Process Skeletal Muscle Tissue Growth Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Striated Muscle Cell Differentiation Positive Regulation Of Signal Transduction Negative Regulation Of Oocyte Development	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Cell Death Death Positive Regulation Of Peptidase Activity Programmed Necrotic Cell Death Necrotic Cell Death Necroptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Response To Inorganic Substance Membrane Organization Inflammatory Cell Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Response To Metal Ion Response To Calcium Ion Apoptotic Signaling Pathway T Cell Apoptotic Process Cell Separation After Cytokinesis Regulation Of Endopeptidase Activity Virion Assembly Regulation Of Peptidase Activity Necroptotic Process Regulation Of Cell Death Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Proteolysis Mitochondrial Membrane Organization Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of ERBB Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Motor Neuron Apoptotic Process Regulation Of Apoptotic Process Mitochondrion Organization Cytokinesis, Completion Of Separation Senescence-associated Heterochromatin Focus Assembly Endosomal Lumen Acidification
Tagcloud ?		112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation igf1 imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Difference) ?		112g 11p15 1291delt 45m 6psi ccdc8 cul7 encompasses genetics ghi ghr height homozygous hypomethylation igf1 imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	adp bax bcl caspase cdk4 cisplatin cleavages define irradiation luciferase ovarian overexpressing p16 p21 p27 parp pdk1 poly pro programmed regulators ribose skov suppressing tnfalpha tumorigenesis uv xl
Tagcloud (Intersection) ?