IFNG and STAT6

Number of citations of the paper that reports this interaction (PMID 9651359)
3

Data Source:
BioGRID (pull down)

		IFNG	STAT6
Gene Name		interferon, gamma	signal transducer and activator of transcription 6, interleukin-4 induced
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Nuclear Chromatin Nucleoplasm Cytoplasm Cytosol Membrane Raft
	Molecular Function	Cytokine Activity Interferon-gamma Receptor Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Neutrophil Apoptotic Process Regulation Of The Force Of Heart Contraction Positive Regulation Of Mesenchymal Cell Proliferation Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Movement Of Cell Or Subcellular Component Humoral Immune Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Neutrophil Chemotaxis Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Myelination Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Insulin Secretion Sensory Perception Of Mechanical Stimulus Positive Regulation Of Membrane Protein Ectodomain Proteolysis Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-18 Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Extrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Action Potential Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Regulation Of Hepatocyte Proliferation	Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Type I Interferon Production Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Reactive Nitrogen Species
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Signaling by PDGF Downstream signal transduction Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines Innate Immune System
Drugs		Olsalazine Glucosamine
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228799 21297633 19122664)	Eosinophilic esophagitis (pediatric) ( 20208534) IgE levels ( 22075330)
Protein-Protein Interactions		5 interactors: IFNGR1 IFNGR2 PDIA3 STAT6 TNF	37 interactors: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 HIST2H3C IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		3458	6778
HPRD ID		00957	03302
Ensembl ID		ENSG00000111537	ENSG00000166888
Uniprot IDs		P01579	A8K4S9 B4DQB3 P42226
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES	1OJ5
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Immune Response Response To Virus Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Regulation Of Immune System Process Defense Response Response To Stress Epithelial Cell Proliferation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Protein Import Into Nucleus Negative Regulation Of Immune Response Response To Other Organism Nuclear Import Interferon-gamma-mediated Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Adaptive Immune Response Innate Immune Response Cellular Response To Interferon-gamma T-helper 1 Cell Lineage Commitment Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Gold Nanoparticle Gland Morphogenesis Protein Import Response To Interferon-gamma Protein Localization To Nucleus Signal Transduction Response To Organic Substance Positive Regulation Of Interleukin-18 Production Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Sequestering Of Triglyceride Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Cell Communication	Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Gene Expression Regulation Of Gene Expression RNA Metabolic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune Response Cellular Nitrogen Compound Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Hormone Response To Stress Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Immune System Process Positive Regulation Of Cytokine Production Response To Cytokine Regulation Of Cellular Process Response To Biotic Stimulus Cellular Response To Hormone Stimulus Cellular Metabolic Process Innate Immune Response Regulation Of Cell Differentiation
Tagcloud ?		30min ancestry asks asleep habitual ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Difference) ?		30min ancestry asks asleep habitual ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Intersection) ?